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- NCIT_C38131 IAO_0000115 "A synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents." @default.
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- NCIT_C38131 NCIT_P106 "Organic Chemical" @default.
- NCIT_C38131 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C38131 NCIT_P107 "Ispinesib" @default.
- NCIT_C38131 NCIT_P108 "Ispinesib" @default.
- NCIT_C38131 NCIT_P175 "727990" @default.
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- NCIT_C38131 NCIT_P325 "A substance being studied in the treatment of cancer. Ispinesib blocks a protein that tumor cells need to divide. It is a type of mitotic inhibitor." @default.
- NCIT_C38131 NCIT_P329 "391236" @default.
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- NCIT_C38131 NCIT_P375 "Ispinesib" @default.
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- NCIT_C38131 hasExactSynonym "CK0238273" @default.
- NCIT_C38131 hasExactSynonym "ISPINESIB" @default.
- NCIT_C38131 hasExactSynonym "Ispinesib" @default.
- NCIT_C38131 hasExactSynonym "SB-715992" @default.
- NCIT_C38131 hasExactSynonym "ispinesib" @default.
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- NCIT_C38131 type Class @default.
- NCIT_C38131 isDefinedBy ncit.owl @default.
- NCIT_C38131 label "Ispinesib" @default.
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