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- NCIT_C385 IAO_0000115 "An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes and other inflammatory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leukocyte chemotaxis/migration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals." @default.
- NCIT_C385 NCIT_NHC0 "C385" @default.
- NCIT_C385 NCIT_P106 "Organic Chemical" @default.
- NCIT_C385 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C385 NCIT_P108 "Colchicine" @default.
- NCIT_C385 NCIT_P175 "757" @default.
- NCIT_C385 NCIT_P207 "C0009262" @default.
- NCIT_C385 NCIT_P210 "64-86-8" @default.
- NCIT_C385 NCIT_P319 "SML2Y3J35T" @default.
- NCIT_C385 NCIT_P322 "FDA" @default.
- NCIT_C385 NCIT_P325 "A drug used to treat gout (inflamed joints caused by a buildup of uric acid). It comes from the crocus plant Colchicum autumnale. Colchicine blocks cell division and the movement of certain immune cells to areas that are inflamed. It is a type of alkaloid and a type of mitotic inhibitor." @default.
- NCIT_C385 NCIT_P329 "39188" @default.
- NCIT_C385 NCIT_P330 "39188" @default.
- NCIT_C385 NCIT_P350 "C22H25NO6" @default.
- NCIT_C385 NCIT_P366 "Colchicine" @default.
- NCIT_C385 NCIT_P368 "CHEBI:27882" @default.
- NCIT_C385 NCIT_P399 "39188" @default.
- NCIT_C385 NCIT_R124 NCIT_C17828 @default.
- NCIT_C385 NCIT_R124 NCIT_C20480 @default.
- NCIT_C385 NCIT_R124 NCIT_C40795 @default.
- NCIT_C385 NCIT_R124 NCIT_C40798 @default.
- NCIT_C385 normalizedInformationContent "100" @default.
- NCIT_C385 referenceCount "1" @default.
- NCIT_C385 hasExactSynonym "(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide" @default.
- NCIT_C385 hasExactSynonym "COLCHICINE" @default.
- NCIT_C385 hasExactSynonym "Colchicine" @default.
- NCIT_C385 hasExactSynonym "Colcrys" @default.
- NCIT_C385 hasExactSynonym "Mitigare" @default.
- NCIT_C385 hasExactSynonym "colchicine" @default.
- NCIT_C385 inSubset NCIT_C173381 @default.
- NCIT_C385 inSubset NCIT_C173383 @default.
- NCIT_C385 inSubset NCIT_C176424 @default.
- NCIT_C385 inSubset NCIT_C63923 @default.
- NCIT_C385 type Class @default.
- NCIT_C385 isDefinedBy ncit.owl @default.
- NCIT_C385 label "Colchicine" @default.
- NCIT_C385 subClassOf NCIT_C186664 @default.
- NCIT_C385 subClassOf NCIT_C1908 @default.
- NCIT_C385 subClassOf NCIT_C1909 @default.
- NCIT_C385 subClassOf NCIT_C25974 @default.
- NCIT_C385 subClassOf NCIT_C273 @default.
- NCIT_C385 subClassOf NCIT_C274 @default.
- NCIT_C385 subClassOf NCIT_C385 @default.
- NCIT_C385 subClassOf NCIT_C67421 @default.