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- NCIT_C38567 IAO_0000115 "Encoded by human NOS2B Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2B binds FAD and FMN cofactors, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2B may bind SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. (NCI)" @default.
- NCIT_C38567 NCIT_NHC0 "C38567" @default.
- NCIT_C38567 NCIT_P100 "600719" @default.
- NCIT_C38567 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C38567 NCIT_P106 "Enzyme" @default.
- NCIT_C38567 NCIT_P108 "Nitric Oxide Synthase 2B" @default.
- NCIT_C38567 NCIT_P200 "Nitric_Oxide_Synthetase" @default.
- NCIT_C38567 NCIT_P204 "Gene_Product_Encoded_By_Gene some 'NOS2B Gene'" @default.
- NCIT_C38567 NCIT_P204 "Gene_Product_Has_Biochemical_Function some Oxidoreductase" @default.
- NCIT_C38567 NCIT_P204 "Gene_Product_Plays_Role_In_Biological_Process some 'Cell-Mediated Cytotoxicity'" @default.
- NCIT_C38567 NCIT_P204 "Gene_Product_Plays_Role_In_Biological_Process some 'Immune Cell Activation Process'" @default.
- NCIT_C38567 NCIT_P204 "Gene_Product_Plays_Role_In_Biological_Process some 'Intercellular Communication Process'" @default.
- NCIT_C38567 NCIT_P204 "Gene_Product_Plays_Role_In_Biological_Process some Oxidation/Reduction" @default.
- NCIT_C38567 NCIT_P310 "Retired_Concept" @default.
- NCIT_C38567 NCIT_P366 "Nitric_Oxide_Synthase-2B" @default.
- NCIT_C38567 NCIT_P93 "P81272" @default.
- NCIT_C38567 NCIT_P98 "Wed Sep 26 15:23:14 EDT 2012 - P81272 has been designated Obsolete and deleted by UniProtKB/Swiss-Prot. The NOS2B gene is a pseudogene. No protein is encoded." @default.
- NCIT_C38567 normalizedInformationContent "100" @default.
- NCIT_C38567 referenceCount "1" @default.
- NCIT_C38567 hasExactSynonym "NOS Type IIB" @default.
- NCIT_C38567 hasExactSynonym "NOS2B" @default.
- NCIT_C38567 hasExactSynonym "NOSIIB" @default.
- NCIT_C38567 hasExactSynonym "Nitric Oxide Synthase 2B" @default.
- NCIT_C38567 hasExactSynonym "Nitric Oxide Synthase IIB" @default.
- NCIT_C38567 type Class @default.
- NCIT_C38567 isDefinedBy ncit.owl @default.
- NCIT_C38567 label "Nitric Oxide Synthase 2B" @default.
- NCIT_C38567 subClassOf NCIT_C104171 @default.
- NCIT_C38567 subClassOf NCIT_C28428 @default.
- NCIT_C38567 subClassOf NCIT_C38567 @default.
- NCIT_C38567 deprecated "true" @default.