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- NCIT_C38610 IAO_0000115 "Adenosine receptor A1 (326 aa, ~37 kDa) is encoded by the human ADORA1 gene. This protein is involved in signal transduction, apoptosis, phagocytosis, inflammatory response and nervous system development." @default.
- NCIT_C38610 NCIT_NHC0 "C38610" @default.
- NCIT_C38610 NCIT_P100 "102775" @default.
- NCIT_C38610 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C38610 NCIT_P106 "Receptor" @default.
- NCIT_C38610 NCIT_P108 "Adenosine Receptor A1" @default.
- NCIT_C38610 NCIT_P207 "C0001451" @default.
- NCIT_C38610 NCIT_P366 "Adenosine-A1_Receptor" @default.
- NCIT_C38610 NCIT_P93 "P30542" @default.
- NCIT_C38610 NCIT_P98 "Widely expressed (ubiquitous in CNS) by human ADORA1 Gene (GPCR1 Family), conserved 326-aa 37-kDa Adenosine A1 Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to suppress cAMP accumulation through adenylate cyclase inhibition and regulate diverse physiologic functions including cardiac rate and contractility, smooth muscle tone, sedation, release of neurotransmitters, platelet function, lipolysis, renal function, white blood cell function, and spermatozoal capacitation. ADORA1 appears to colocalize with adenosine deaminase, which may be necessary for high affinity agonist binding. A potent biologic mediator, most effects of adenosine protect cells during stress." @default.
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- NCIT_C38610 normalizedInformationContent "100" @default.
- NCIT_C38610 referenceCount "1" @default.
- NCIT_C38610 hasExactSynonym "ADORA1" @default.
- NCIT_C38610 hasExactSynonym "Adenosine A1 Receptor" @default.
- NCIT_C38610 hasExactSynonym "Adenosine Receptor A1" @default.
- NCIT_C38610 type Class @default.
- NCIT_C38610 isDefinedBy ncit.owl @default.
- NCIT_C38610 label "Adenosine Receptor A1" @default.
- NCIT_C38610 subClassOf NCIT_C17021 @default.
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