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- NCIT_C38690 IAO_0000115 "A mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived from the extracellular phosphomannan of the yeast Pichia (Hansenula) holstii, with potential antiangiogenic activity. Muparfostat inhibits the endo-beta-D-glucuronidase heparanase, which may interfere with the heparanase-mediated degradation of heparan-sulfate proteoglycans in extracellular matrices, an important step in the metastatic process. This agent may also bind with high affinity to the heparan sulfate-binding domains of vascular endothelial growth factor (VEGF) and fibroblast growth factors 1 and 2, thereby reducing their functional activities and inhibiting VEGF and FGF stimulation of tumor angiogenesis. Increased heparanase activity has been implicated in tumor angiogenesis and metastasis." @default.
- NCIT_C38690 NCIT_A32 NCIT_C1909 @default.
- NCIT_C38690 NCIT_NHC0 "C38690" @default.
- NCIT_C38690 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C38690 NCIT_P107 "Muparfostat" @default.
- NCIT_C38690 NCIT_P108 "Muparfostat" @default.
- NCIT_C38690 NCIT_P207 "C0769628" @default.
- NCIT_C38690 NCIT_P210 "1020105-89-8" @default.
- NCIT_C38690 NCIT_P302 "Malignant melanoma" @default.
- NCIT_C38690 NCIT_P319 "P2BKS6T40H" @default.
- NCIT_C38690 NCIT_P322 "CTRP" @default.
- NCIT_C38690 NCIT_P322 "FDA" @default.
- NCIT_C38690 NCIT_P322 "GDC" @default.
- NCIT_C38690 NCIT_P325 "A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antiangiogenesis agents." @default.
- NCIT_C38690 NCIT_P329 "339562" @default.
- NCIT_C38690 NCIT_P330 "339562" @default.
- NCIT_C38690 NCIT_P366 "PI-88" @default.
- NCIT_C38690 NCIT_P375 "Muparfostat" @default.
- NCIT_C38690 NCIT_P399 "339562" @default.
- NCIT_C38690 normalizedInformationContent "100" @default.
- NCIT_C38690 referenceCount "1" @default.
- NCIT_C38690 hasExactSynonym "6-O-(dihydrogen Phosphate)-2,3,4-tris-O-(hydrogen Sulfate)-alpha-d-mannopyranosyl-(1->poly(3)-2,4,6-tris-O-(hydrogen Sulfate)-alpha-d-mannopyranosyl-(1->)2)-1,3,4,6-tetrakis-O-(hydrogen Sulfate)-d-mannopyranose" @default.
- NCIT_C38690 hasExactSynonym "MUPARFOSTAT" @default.
- NCIT_C38690 hasExactSynonym "Muparfostat" @default.
- NCIT_C38690 hasExactSynonym "PI 88" @default.
- NCIT_C38690 hasExactSynonym "PI-88" @default.
- NCIT_C38690 hasExactSynonym "Phosphomannopentose Sulfate PI-88" @default.
- NCIT_C38690 hasExactSynonym "Sulfated Phosphomanno-oligosaccharide PI-88" @default.
- NCIT_C38690 hasExactSynonym "alpha-D-Mannan, (1->3)-, 6-(Dihydrogen Phosphate) Tris(Hydrogen Sulfate)" @default.
- NCIT_C38690 inSubset NCIT_C116977 @default.
- NCIT_C38690 inSubset NCIT_C116978 @default.
- NCIT_C38690 inSubset NCIT_C128784 @default.
- NCIT_C38690 inSubset NCIT_C157711 @default.
- NCIT_C38690 inSubset NCIT_C157712 @default.
- NCIT_C38690 inSubset NCIT_C176424 @default.
- NCIT_C38690 inSubset NCIT_C177537 @default.
- NCIT_C38690 inSubset NCIT_C63923 @default.
- NCIT_C38690 type Class @default.
- NCIT_C38690 isDefinedBy ncit.owl @default.
- NCIT_C38690 label "Muparfostat" @default.
- NCIT_C38690 subClassOf NCIT_C1742 @default.
- NCIT_C38690 subClassOf NCIT_C1908 @default.
- NCIT_C38690 subClassOf NCIT_C1909 @default.
- NCIT_C38690 subClassOf NCIT_C1971 @default.
- NCIT_C38690 subClassOf NCIT_C263 @default.
- NCIT_C38690 subClassOf NCIT_C274 @default.
- NCIT_C38690 subClassOf NCIT_C38690 @default.
- NCIT_C38690 subClassOf NCIT_C78275 @default.