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- NCIT_C38713 IAO_0000115 "An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes." @default.
- NCIT_C38713 NCIT_A32 NCIT_C1909 @default.
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- NCIT_C38713 NCIT_A7 NCIT_C30164 @default.
- NCIT_C38713 NCIT_NHC0 "C38713" @default.
- NCIT_C38713 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C38713 NCIT_P107 "Dasatinib" @default.
- NCIT_C38713 NCIT_P108 "Dasatinib" @default.
- NCIT_C38713 NCIT_P175 "732517" @default.
- NCIT_C38713 NCIT_P207 "C1455147" @default.
- NCIT_C38713 NCIT_P210 "863127-77-9" @default.
- NCIT_C38713 NCIT_P302 "Chronic myeloid leukemia; Philadelphia chromosome-positive acute lymphoblastic leukemia" @default.
- NCIT_C38713 NCIT_P319 "RBZ1571X5H" @default.
- NCIT_C38713 NCIT_P322 "CTRP" @default.
- NCIT_C38713 NCIT_P322 "FDA" @default.
- NCIT_C38713 NCIT_P322 "GDC" @default.
- NCIT_C38713 NCIT_P325 "A drug used to treat certain types of chronic myeloid leukemia and acute lymphoblastic leukemia. BMS-354825 is also being studied in the treatment of certain other blood diseases and types of cancer. BMS-354825 binds to and blocks BCR-ABL and other proteins that help cancer cells grow. It is a type of tyrosine kinase inhibitor." @default.
- NCIT_C38713 NCIT_P329 "315885" @default.
- NCIT_C38713 NCIT_P330 "315885" @default.
- NCIT_C38713 NCIT_P350 "C22H26ClN7O2S.H2O" @default.
- NCIT_C38713 NCIT_P366 "BMS-354825" @default.
- NCIT_C38713 NCIT_P375 "Dasatinib" @default.
- NCIT_C38713 NCIT_P399 "315885" @default.
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- NCIT_C38713 NCIT_R146 NCIT_C16554 @default.
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- NCIT_C38713 NCIT_R146 NCIT_C17893 @default.
- NCIT_C38713 NCIT_R146 NCIT_C20027 @default.
- NCIT_C38713 NCIT_R146 NCIT_C26548 @default.
- NCIT_C38713 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C38713 referenceCount "2" @default.
- NCIT_C38713 hasExactSynonym "5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-, Monohydrate" @default.
- NCIT_C38713 hasExactSynonym "BMS-354825" @default.
- NCIT_C38713 hasExactSynonym "DASATINIB" @default.
- NCIT_C38713 hasExactSynonym "Dasatinib Hydrate" @default.
- NCIT_C38713 hasExactSynonym "Dasatinib Monohydrate" @default.
- NCIT_C38713 hasExactSynonym "Dasatinib" @default.
- NCIT_C38713 hasExactSynonym "Sprycel" @default.
- NCIT_C38713 hasExactSynonym "dasatinib" @default.
- NCIT_C38713 inSubset NCIT_C116977 @default.
- NCIT_C38713 inSubset NCIT_C116978 @default.
- NCIT_C38713 inSubset NCIT_C128784 @default.
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- NCIT_C38713 inSubset NCIT_C177537 @default.
- NCIT_C38713 inSubset NCIT_C63923 @default.
- NCIT_C38713 type Class @default.
- NCIT_C38713 isDefinedBy ncit.owl @default.
- NCIT_C38713 label "Dasatinib" @default.
- NCIT_C38713 subClassOf B0b569c538eef4ea7e100ca1cb525fa74 @default.
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