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- NCIT_C38719 IAO_0000115 "A combination of the thiosemicarbazone 3-aminopyridine-2-carboxaldehyde (3-AP) and the nucleoside analogue fludarabine with antineoplastic activity. The agents in 3-AP/fludarabine, act synergistically to inhibit the enzyme ribonucleotide reductase.. Composed of two subunits, this enzyme catalyzes the rate-limiting step in the conversion of ribonucleotides to deoxyribonucleotides. The 3-AP binds to and inactivates one subunit while fludarabine binds to and inactivates the other. Fludarabine also inhibits DNA polymerase alpha and DNA primase. At low concentrations, this agent arrests tumor cells in the S-phase of the cell cycle; at higher concentrations, in the G0/G1 phase of the cell cycle. (NCI04)" @default.
- NCIT_C38719 NCIT_NHC0 "C38719" @default.
- NCIT_C38719 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C38719 NCIT_P108 "3-AP/Fludarabine" @default.
- NCIT_C38719 NCIT_P207 "C1328164" @default.
- NCIT_C38719 NCIT_P310 "Obsolete_Concept" @default.
- NCIT_C38719 NCIT_P366 "_3-AP_Fludarabine" @default.
- NCIT_C38719 NCIT_R123 NCIT_C1094 @default.
- NCIT_C38719 NCIT_R123 NCIT_C1556 @default.
- NCIT_C38719 NCIT_R123 NCIT_C186664 @default.
- NCIT_C38719 NCIT_R123 NCIT_C1908 @default.
- NCIT_C38719 NCIT_R123 NCIT_C1909 @default.
- NCIT_C38719 NCIT_R123 NCIT_C2150 @default.
- NCIT_C38719 NCIT_R123 NCIT_C2242 @default.
- NCIT_C38719 NCIT_R123 NCIT_C272 @default.
- NCIT_C38719 NCIT_R123 NCIT_C274 @default.
- NCIT_C38719 NCIT_R123 NCIT_C471 @default.
- NCIT_C38719 normalizedInformationContent "100" @default.
- NCIT_C38719 referenceCount "1" @default.
- NCIT_C38719 hasExactSynonym "3-AP/Fludarabine" @default.
- NCIT_C38719 hasExactSynonym "3AP/FAMP" @default.
- NCIT_C38719 type Class @default.
- NCIT_C38719 isDefinedBy ncit.owl @default.
- NCIT_C38719 label "3-AP/Fludarabine" @default.
- NCIT_C38719 subClassOf B28cc628ebc488cb3c47daec34b2ac2de @default.
- NCIT_C38719 subClassOf B8a88490480fc4458b525710baf27359e @default.
- NCIT_C38719 subClassOf B94bc18e8520d22e5d19b0806d838c676 @default.
- NCIT_C38719 subClassOf Ba2a186b3b9a5fc8a6465ca7995b6287a @default.
- NCIT_C38719 subClassOf NCIT_C12218 @default.
- NCIT_C38719 subClassOf NCIT_C38719 @default.
- NCIT_C38719 subClassOf NCIT_C61063 @default.
- NCIT_C38719 subClassOf NCIT_C62633 @default.