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- NCIT_C38794 NCIT_NHC0 "C38794" @default.
- NCIT_C38794 NCIT_P106 "Functional Concept" @default.
- NCIT_C38794 NCIT_P108 "Cell Cycle Pathway" @default.
- NCIT_C38794 NCIT_P208 "CL322969" @default.
- NCIT_C38794 NCIT_P215 "hsa04110" @default.
- NCIT_C38794 NCIT_P325 "Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated." @default.
- NCIT_C38794 NCIT_P366 "Cell_Cycle_Pathway" @default.
- NCIT_C38794 normalizedInformationContent "66.293829062568449" @default.
- NCIT_C38794 referenceCount "163" @default.
- NCIT_C38794 hasExactSynonym "Cell Cycle Pathway" @default.
- NCIT_C38794 hasExactSynonym "Cell Cycle" @default.
- NCIT_C38794 type Class @default.
- NCIT_C38794 isDefinedBy ncit.owl @default.
- NCIT_C38794 label "Cell Cycle Pathway" @default.
- NCIT_C38794 subClassOf NCIT_C19779 @default.
- NCIT_C38794 subClassOf NCIT_C20633 @default.
- NCIT_C38794 subClassOf NCIT_C38794 @default.
- NCIT_C38794 subClassOf NCIT_C39700 @default.