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- NCIT_C38800 NCIT_NHC0 "C38800" @default.
- NCIT_C38800 NCIT_P106 "Functional Concept" @default.
- NCIT_C38800 NCIT_P108 "Steroid Hormone Biosynthesis Pathway" @default.
- NCIT_C38800 NCIT_P207 "C0597517" @default.
- NCIT_C38800 NCIT_P215 "hsa00140" @default.
- NCIT_C38800 NCIT_P325 "Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 compound, to the first C21 steroid, pregnenolone, which is converted by a bifunctional enzyme complex to the gestagen hormone, progesterone. Pregnenolone and progesterone are the starting materials for the three groups of steroids: C21 steroids of glucocorticoids and mineralocorticoids, C19 steroids of androgens, and C18 steroids of estrogens. (i) Progesterone is converted by hydroxylations at carbons 21 and 11 to corticosterone, which is further modified by hydroxylation and oxydoreduction at carbon 18 to yield aldosterone, a mineralcorticoid. Cortisol, the main glucocorticoid, is formed from 17alpha-hydroxyprogesterone with 11-deoxycortisol as an intermediate. (ii) Male hormone testosterone is formed from pregnenolone by two pathways, delta5 pathway via dehydroepiandrosterone and delta4 pathway via androstenedione. The enzyme CYP17A1 is responsible for the 17,20 lyase and 17alpha-hydroxylase activities in respective pathways. (iii) Female hormones estrone and estradiol are formed from testosterone and 4-androstene-3,17-dione by oxidative removal of the C19 methyl group and subsequent aromatization of ring A. In addition to these three groups, recent studies show that there is another group, termed neurosteroids, synthesized in the brain rather than the peripheral endocrine gland." @default.
- NCIT_C38800 NCIT_P366 "C21-Steroid_Hormone_Metabolism_Pathway" @default.
- NCIT_C38800 NCIT_P98 "KEGG merged hsa00150 with hsa00140." @default.
- NCIT_C38800 normalizedInformationContent "71.519303452612405" @default.
- NCIT_C38800 referenceCount "74" @default.
- NCIT_C38800 hasExactSynonym "Androgen and Estrogen Metabolism" @default.
- NCIT_C38800 hasExactSynonym "C21-Steroid Hormone Metabolism" @default.
- NCIT_C38800 hasExactSynonym "Steroid Hormone Biosynthesis Pathway" @default.
- NCIT_C38800 hasExactSynonym "Steroid Hormone Biosynthesis" @default.
- NCIT_C38800 type Class @default.
- NCIT_C38800 isDefinedBy ncit.owl @default.
- NCIT_C38800 label "Steroid Hormone Biosynthesis Pathway" @default.
- NCIT_C38800 subClassOf NCIT_C18611 @default.
- NCIT_C38800 subClassOf NCIT_C20633 @default.
- NCIT_C38800 subClassOf NCIT_C38800 @default.
- NCIT_C38800 subClassOf NCIT_C39728 @default.