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- NCIT_C38822 NCIT_NHC0 "C38822" @default.
- NCIT_C38822 NCIT_P106 "Functional Concept" @default.
- NCIT_C38822 NCIT_P108 "Glycosylphosphatidylinositol-Anchor Biosynthesis Pathway" @default.
- NCIT_C38822 NCIT_P207 "C1512236" @default.
- NCIT_C38822 NCIT_P215 "hsa00563" @default.
- NCIT_C38822 NCIT_P325 "Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol (GPI) anchor. Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals. All protein-linked GPI anchors share a common core structure, characterized by the substructure Man (a1-4) GlcN (a1-6) myo-inositol-1P-lipid. Biosynthesis of GPI anchors proceeds in three stages: (i) preassembly of a GPI precursor in the ER membrane, (ii) attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER, and (iii) lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi. Defects of GPI anchor biosynthesis genes result in a genetic disorder, paroxysmal nocturnal hemoglobinuria." @default.
- NCIT_C38822 NCIT_P366 "Glycosylphosphatidylinositol-anchor_Biosynthesis_Pathway" @default.
- NCIT_C38822 normalizedInformationContent "88.143637090998837" @default.
- NCIT_C38822 referenceCount "6" @default.
- NCIT_C38822 hasExactSynonym "GPI-Anchor Biosynthesis Pathway" @default.
- NCIT_C38822 hasExactSynonym "Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis" @default.
- NCIT_C38822 hasExactSynonym "Glycosylphosphatidylinositol-Anchor Biosynthesis Pathway" @default.
- NCIT_C38822 type Class @default.
- NCIT_C38822 isDefinedBy ncit.owl @default.
- NCIT_C38822 label "Glycosylphosphatidylinositol-Anchor Biosynthesis Pathway" @default.
- NCIT_C38822 subClassOf NCIT_C18611 @default.
- NCIT_C38822 subClassOf NCIT_C20633 @default.
- NCIT_C38822 subClassOf NCIT_C38822 @default.
- NCIT_C38822 subClassOf NCIT_C39732 @default.