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- NCIT_C38834 NCIT_NHC0 "C38834" @default.
- NCIT_C38834 NCIT_P106 "Functional Concept" @default.
- NCIT_C38834 NCIT_P108 "MAPK Signaling Pathway" @default.
- NCIT_C38834 NCIT_P207 "C1518102" @default.
- NCIT_C38834 NCIT_P215 "hsa04010" @default.
- NCIT_C38834 NCIT_P325 "The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli." @default.
- NCIT_C38834 NCIT_P366 "MAPK_Signaling_Pathway" @default.
- NCIT_C38834 normalizedInformationContent "61.256039797661508" @default.
- NCIT_C38834 referenceCount "349" @default.
- NCIT_C38834 hasExactSynonym "MAPK Signaling Pathway" @default.
- NCIT_C38834 type Class @default.
- NCIT_C38834 isDefinedBy ncit.owl @default.
- NCIT_C38834 label "MAPK Signaling Pathway" @default.
- NCIT_C38834 subClassOf NCIT_C17132 @default.
- NCIT_C38834 subClassOf NCIT_C20633 @default.
- NCIT_C38834 subClassOf NCIT_C38834 @default.