Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C38897> ?p ?o ?g. }
Showing items 1 to 33 of
33
with 100 items per page.
- NCIT_C38897 IAO_0000115 "Consisting of cell surface type I membrane Delta, Epsilon, Gamma, Zeta, and Eta protein subunits with ITAM domains and noncovalently associated with the disulfide bound heterodimeric alpha/beta and gamma/delta TCR, the CD3 complex couples receptor antigen recognition to signal transduction pathways during T-cell activation. During TCR engagement with MHC-associated antigen on host cell surfaces and synapse formation, CD3 activity leads to Tyr-phosphorylated CD3 subunits, Tyr phosphorylation of LAT colocalized in lipid rafts, and MAPK activation. CD3 signal transduction appears to involve LCK, ZAP70, Nck, SLA, SLA2, and DOCK2. CD3 subunits may also associate with the cytoskeleton. CD3 also mediates TCR signal transduction during the developmental transition through positive selection of immature thymocytes to mature CD4+ or CD8+ T cells. (NCI)" @default.
- NCIT_C38897 NCIT_A32 NCIT_C268 @default.
- NCIT_C38897 NCIT_NHC0 "C38897" @default.
- NCIT_C38897 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C38897 NCIT_P107 "CD3 Complex" @default.
- NCIT_C38897 NCIT_P108 "CD3 Complex" @default.
- NCIT_C38897 NCIT_P207 "C0108779" @default.
- NCIT_C38897 NCIT_P322 "CTRP" @default.
- NCIT_C38897 NCIT_P322 "GDC" @default.
- NCIT_C38897 NCIT_P366 "CD3_Complex" @default.
- NCIT_C38897 NCIT_P375 "CD3" @default.
- NCIT_C38897 NCIT_R51 NCIT_C17065 @default.
- NCIT_C38897 NCIT_R51 NCIT_C21176 @default.
- NCIT_C38897 NCIT_R51 NCIT_C26548 @default.
- NCIT_C38897 normalizedInformationContent "89.350088392419622" @default.
- NCIT_C38897 referenceCount "5" @default.
- NCIT_C38897 hasExactSynonym "CD3 Complex" @default.
- NCIT_C38897 hasExactSynonym "CD3" @default.
- NCIT_C38897 hasExactSynonym "T-Cell Surface Glycoprotein CD3" @default.
- NCIT_C38897 hasExactSynonym "T3 Complex" @default.
- NCIT_C38897 inSubset NCIT_C116977 @default.
- NCIT_C38897 inSubset NCIT_C142799 @default.
- NCIT_C38897 inSubset NCIT_C142800 @default.
- NCIT_C38897 inSubset NCIT_C157711 @default.
- NCIT_C38897 inSubset NCIT_C177537 @default.
- NCIT_C38897 type Class @default.
- NCIT_C38897 isDefinedBy ncit.owl @default.
- NCIT_C38897 label "CD3 Complex" @default.
- NCIT_C38897 subClassOf B2eff0d0c1064103a4139d8f35fc6b13c @default.
- NCIT_C38897 subClassOf Bb64b9db734f476ea47416eb98dbe2f64 @default.
- NCIT_C38897 subClassOf NCIT_C21176 @default.
- NCIT_C38897 subClassOf NCIT_C26548 @default.
- NCIT_C38897 subClassOf NCIT_C38897 @default.