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- NCIT_C38969 NCIT_NHC0 "C38969" @default.
- NCIT_C38969 NCIT_P106 "Functional Concept" @default.
- NCIT_C38969 NCIT_P108 "Angiotensin-converting Enzyme 2 Pathway" @default.
- NCIT_C38969 NCIT_P207 "C1510889" @default.
- NCIT_C38969 NCIT_P216 "h_ace2Pathway" @default.
- NCIT_C38969 NCIT_P325 "Cardiovascular diseases are predicted to be the most common cause of death worldwide by 2020. The major regulator of blood pressure homeostasis is the renin-angiotensin system. Angiotensinogen is digested by renin to produce angiotensin I (AGT I). AGT I is an inactive 10 amino-acid peptide that is further degraded to produce angiotensin II by the angiotensin-converting enzyme (ACE). Angiotensin II is the master regulator of blood pressure increase acting on the heart, kidneys and blood vessels. Angiotensin II causes direct constriction of the resistance vessels and stimulation of the adrenal thereby increasing blood volume and sodium absorption. In 2000, Tipnis et al. discovered ACE 2 a second carboxypeptidase that digests angiotensin. ACE is a di-peptidase, cleaving off 2 peptides from the c-terminal end of angiotensin. ACE 2 only cleaves 1 amino acid to produce angiotensin 1-9 (AGT 1-9) which has no identified function at this time. AGT 1-9 is not converted to angiotensin II but further degraded by ACE to AGT 1-7, a vasodilator. It would appear that ACE 2 inhibits the formation of angiotensin and reduces blood pressure increases. Crackower et al determined that ace2 -/- mice suffered significant heart defects at 6 months. Further deletion of ACE resulted in restored cardiac functions. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C38969 NCIT_P366 "Angiotensin-converting_Enzyme_2_Pathway" @default.
- NCIT_C38969 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C38969 normalizedInformationContent "81.653330900245635" @default.
- NCIT_C38969 referenceCount "16" @default.
- NCIT_C38969 hasExactSynonym "Angiotensin-converting Enzyme 2 Pathway" @default.
- NCIT_C38969 hasExactSynonym "Angiotensin-converting enzyme 2 regulates heart function" @default.
- NCIT_C38969 type Class @default.
- NCIT_C38969 isDefinedBy ncit.owl @default.
- NCIT_C38969 label "Angiotensin-converting Enzyme 2 Pathway" @default.
- NCIT_C38969 subClassOf NCIT_C19779 @default.
- NCIT_C38969 subClassOf NCIT_C20633 @default.
- NCIT_C38969 subClassOf NCIT_C38969 @default.
- NCIT_C38969 subClassOf NCIT_C91822 @default.