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- NCIT_C38978 NCIT_NHC0 "C38978" @default.
- NCIT_C38978 NCIT_P106 "Functional Concept" @default.
- NCIT_C38978 NCIT_P108 "Stress Fiber Formation Pathway" @default.
- NCIT_C38978 NCIT_P207 "C1514990" @default.
- NCIT_C38978 NCIT_P216 "h_akap13Pathway" @default.
- NCIT_C38978 NCIT_P325 "The A-kinase anchor protein 13 (AKAP13, also known as AKAP-LBC) is one of a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP13 is a splice variant of the oncogene Lbc. Alternative splicing of the AKAP13 gene results in at least 3 transcript variants encoding different isoforms containing a Dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. These splice variants contain a fragment that was originally identified as Ht31 (See Carr et al 1991) which acts as a scaffolding protein to regulate the Rho signaling pathway and as protein kinase A-anchoring protein creating a coordination of these two signaling pathways. Diviani et al. found that in HEK293 cells LPA induced stimulation preferentially activates AKAP13 via G-alpha12. As yet targets for the anchored PKA have not been identified. AKAP13 and Rho do not appear to be phosphorylated by PKA. Diviani et al also found that the Lbc oncogene and protooncogene splice variant show higher activation and stress fiber localization. This appears to be a result of the presence of N terminal inhibitory sequences. A similar model of regulation has been proposed for Dbl and Vav. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C38978 NCIT_P366 "Stress_Fiber_Formation_Pathway" @default.
- NCIT_C38978 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C38978 normalizedInformationContent "82.080392758357064" @default.
- NCIT_C38978 referenceCount "15" @default.
- NCIT_C38978 hasExactSynonym "Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation" @default.
- NCIT_C38978 hasExactSynonym "Stress Fiber Formation Pathway" @default.
- NCIT_C38978 type Class @default.
- NCIT_C38978 isDefinedBy ncit.owl @default.
- NCIT_C38978 label "Stress Fiber Formation Pathway" @default.
- NCIT_C38978 subClassOf NCIT_C17132 @default.
- NCIT_C38978 subClassOf NCIT_C20633 @default.
- NCIT_C38978 subClassOf NCIT_C38978 @default.