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- NCIT_C38980 NCIT_NHC0 "C38980" @default.
- NCIT_C38980 NCIT_P106 "Functional Concept" @default.
- NCIT_C38980 NCIT_P108 "Centrosome Pathway" @default.
- NCIT_C38980 NCIT_P207 "C1516394" @default.
- NCIT_C38980 NCIT_P216 "h_akapCentrosomePathway" @default.
- NCIT_C38980 NCIT_P325 "Protein kinase A regulatory subunit RII-alpha (PKA-RIIa) is tightly bound to centrosomal structures during interphase through interaction with the A-kinase anchoring protein AKAP350 (also known as AKAP450 and CGNAP), MAP2 and Pericentrin. This diagram illustrates these three PKA-RII binding complexes. The cyclin B-p34(cdc2) kinase (CDK1) has been shown to phosphorylate PKA-RIIa on T54 and this has been proposed to alter the subcellular localization of PKA-RIIa at the onset of mitosis. It has been demonstrated that PKA-RIIa dissociates and redistributes from centrosomes at mitosis. The focal point of this illustration is the AKAP350 complex. In addition to binding PKA-RIIa, AKAP350 binds PKN (Takahashi et al 1999) and the phosphatases PP1 and PPA2 (Takahashi et al 1999). PKN is a serine/threonine protein kinase, having a catalytic domain homologous to the PKC family in the C-terminal region and a unique regulatory region in the N-terminal region. PKN is activated by a small GTPase RhoA and unsaturated fatty acids such as arachidonic acid. The binding of both kinases and phosphatases by the same scaffold protein provides a focal point where physiological events, such as cell cycle progression and intracellular membrane traffic, may be regulated by phosphorylation state of specific protein substrates. There are at least 4 isoforms of AKAP350 which lead to the possibility that they may behave differently at different subcellular locations. MAP2 is a member of a group of proteins that provide microtubule stabilization. MAP2 affinity appears to be dependent on PKA phosphorylation of MAP2. Pericentrin is also an AKAP (Diviani and Scott). Pericentrin binds Dynein which is also regulated by PKA leading to the possibility that pericentrin positions PKA to regulate dynein function (Diviani and Scott). (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C38980 NCIT_P366 "Centrosome_Pathway" @default.
- NCIT_C38980 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C38980 normalizedInformationContent "79.251926409996102" @default.
- NCIT_C38980 referenceCount "23" @default.
- NCIT_C38980 hasExactSynonym "Centrosome Pathway" @default.
- NCIT_C38980 hasExactSynonym "Protein Kinase A at the Centrosome" @default.
- NCIT_C38980 type Class @default.
- NCIT_C38980 isDefinedBy ncit.owl @default.
- NCIT_C38980 label "Centrosome Pathway" @default.
- NCIT_C38980 subClassOf NCIT_C19779 @default.
- NCIT_C38980 subClassOf NCIT_C20633 @default.
- NCIT_C38980 subClassOf NCIT_C38980 @default.