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- NCIT_C38981 NCIT_NHC0 "C38981" @default.
- NCIT_C38981 NCIT_P106 "Functional Concept" @default.
- NCIT_C38981 NCIT_P108 "AKT Signaling Pathway" @default.
- NCIT_C38981 NCIT_P207 "C1515844" @default.
- NCIT_C38981 NCIT_P216 "h_aktPathway" @default.
- NCIT_C38981 NCIT_P325 "Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the cytoplasm from the cell surface. PIP3 signals activate the kinase PDK1, 3-phosphoinositide-dependent protein kinase-1, which in turn activates the kinase AKT, also known as protein kinase B. Proteins phosphorylated by activated AKT promote cell survival. Phosphorylation of Ikappa-B kinase leads to activation of the transcription factor NF-kB to oppose apoptosis. Bad is a protein in the Bcl-2 gene family that opposes Bcl-2 to induce apoptosis. Phosphorylation of Bad by AKT blocks anti-apoptotic activity to promote cell survival. Similarly, phosphorylation of the protease caspase 9 or forkhead transcription factors by AKT block the induction of apoptosis by these factors. AKT promotes cell survival and opposes apoptosis by a variety of routes. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C38981 NCIT_P366 "AKT_Signaling_Pathway" @default.
- NCIT_C38981 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C38981 normalizedInformationContent "75.590086567603848" @default.
- NCIT_C38981 referenceCount "40" @default.
- NCIT_C38981 hasExactSynonym "AKT Signaling Pathway" @default.
- NCIT_C38981 type Class @default.
- NCIT_C38981 isDefinedBy ncit.owl @default.
- NCIT_C38981 label "AKT Signaling Pathway" @default.
- NCIT_C38981 subClassOf NCIT_C17132 @default.
- NCIT_C38981 subClassOf NCIT_C20633 @default.
- NCIT_C38981 subClassOf NCIT_C38981 @default.