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- NCIT_C38986 NCIT_NHC0 "C38986" @default.
- NCIT_C38986 NCIT_P106 "Functional Concept" @default.
- NCIT_C38986 NCIT_P108 "Anthrax Toxin Pathway" @default.
- NCIT_C38986 NCIT_P207 "C1510921" @default.
- NCIT_C38986 NCIT_P216 "h_anthraxPathway" @default.
- NCIT_C38986 NCIT_P325 "One of the key causes of anthrax virulence is the action of three specific factors produced by the bacterium Bacillus anthracis. Even with successful antibiotic treatment, anthrax toxins can remain in the circulation and cause lethality. The toxins produced by anthrax bacteria are lethal factor (LF), protective antigen (PA) and edema factor (EF). The entry of toxin into cells begins with the recognition of a cellular receptor in the plasma membrane by PA. Proteolytic cleavage of cell-bound PA creates a smaller fragment that then multimerizes into a pore-like structure in the plasma membrane. The LF and EF proteins bind to the PA pre-pore, followed by internalization of the entire structure through receptor-mediated endocytosis. In the endosomal compartment, the acidic pH causes a conformational change that inserts PA fragments and releases LF and EF into the cytoplasm. In the cytoplasm, LF acts as a protease that cleaves MAP kinase kinase (MAPKK 1 and MAPKK 2), inhibiting pathways that rely on this kinase family and causing cell death. Edema factor is an adenylate cyclase that inhibits the immune response, including phagocytosis by macrophages. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C38986 NCIT_P366 "Anthrax_Toxin_Pathway" @default.
- NCIT_C38986 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C38986 normalizedInformationContent "89.350088392419622" @default.
- NCIT_C38986 referenceCount "5" @default.
- NCIT_C38986 hasExactSynonym "Anthrax Toxin Mechanism of Action" @default.
- NCIT_C38986 hasExactSynonym "Anthrax Toxin Pathway" @default.
- NCIT_C38986 type Class @default.
- NCIT_C38986 isDefinedBy ncit.owl @default.
- NCIT_C38986 label "Anthrax Toxin Pathway" @default.
- NCIT_C38986 subClassOf NCIT_C20633 @default.
- NCIT_C38986 subClassOf NCIT_C38986 @default.
- NCIT_C38986 subClassOf NCIT_C39701 @default.
- NCIT_C38986 subClassOf NCIT_C39738 @default.