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- NCIT_C38990 NCIT_NHC0 "C38990" @default.
- NCIT_C38990 NCIT_P106 "Functional Concept" @default.
- NCIT_C38990 NCIT_P108 "Oxidative Stress Pathway" @default.
- NCIT_C38990 NCIT_P207 "C1518762" @default.
- NCIT_C38990 NCIT_P216 "h_arenrf2Pathway" @default.
- NCIT_C38990 NCIT_P325 "Reactive oxygen species (ROS) are detrimental to cellular health and can damage biological macromolecules. Electrophilic compounds, xenobiotics and antioxidants are sources of reactive oxygen species, creating oxidative stress that can harm cells. Enzymes involved in the Phase II detoxification of xenobiotics to reduce cellular stress include glutathione transferases, quinone reductase, epoxide hydrolase, heme oxygenase, UDP-glucuronosyl transferases, and gamma-glutamylcysteine synthetase. Expression of these genes protects cells from oxidative damage and can prevent mutagenesis and cancer. Transcription of these enzymes is coordinately regulated through antioxidant response elements (AREs). Nrf2 (NF-E2-related factor 2) and Nrf1 are transcription factors that bind to AREs and activate these genes. Inactive Nrf2 is retained in the cytosol by association a complex with the cytoskeletal protein Keap1. Cytosolic Nrf2 is phosphorylated and translocates into the nucleus in response to protein kinase C activation and Map kinase pathways. In the nucleus, Nrf2 activate genes through AREs by interacting with transcription factors in the bZIP family, including CREB, ATF4 and fos or jun. Nrf2 activation of genes is opposed by small maf proteins, including MafG and MafK, maintaining a counterbalance to Nrf2 and balancing the oxidation level of the intracellular environment. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C38990 NCIT_P366 "Oxidative_Stress_Pathway" @default.
- NCIT_C38990 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C38990 normalizedInformationContent "78.700176784839257" @default.
- NCIT_C38990 referenceCount "25" @default.
- NCIT_C38990 hasExactSynonym "Oxidative Stress Induced Gene Expression Via Nrf2" @default.
- NCIT_C38990 hasExactSynonym "Oxidative Stress Pathway" @default.
- NCIT_C38990 type Class @default.
- NCIT_C38990 isDefinedBy ncit.owl @default.
- NCIT_C38990 label "Oxidative Stress Pathway" @default.
- NCIT_C38990 subClassOf NCIT_C19779 @default.
- NCIT_C38990 subClassOf NCIT_C20633 @default.
- NCIT_C38990 subClassOf NCIT_C38990 @default.
- NCIT_C38990 subClassOf NCIT_C91822 @default.