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- NCIT_C38996 NCIT_NHC0 "C38996" @default.
- NCIT_C38996 NCIT_P106 "Functional Concept" @default.
- NCIT_C38996 NCIT_P108 "ATM Signaling Pathway" @default.
- NCIT_C38996 NCIT_P207 "C1510698" @default.
- NCIT_C38996 NCIT_P216 "h_atmPathway" @default.
- NCIT_C38996 NCIT_P325 "The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to DNA stimulates DNA repair and blocks progression through the cell cycle. Mutation of the ATM gene causes the disease ataxia telangiectasia which involves an inherited predisposition to some cancers. To play this role ATM interacts with a broad network of proteins, including checkpoint factors (chk1, chk2), tumor suppressors (p53 and BRCA), DNA repair factors (RAD50, RAD51, GADD45), and other signaling molecules (c-Abl and NF-kB). In addition to regulating DNA repair and the cell cycle, ATM can also trigger apoptosis in radiation treated cells. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C38996 NCIT_P366 "ATM_Signaling_Pathway" @default.
- NCIT_C38996 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C38996 normalizedInformationContent "76.105970727550996" @default.
- NCIT_C38996 referenceCount "37" @default.
- NCIT_C38996 hasExactSynonym "ATM Signaling Pathway" @default.
- NCIT_C38996 type Class @default.
- NCIT_C38996 isDefinedBy ncit.owl @default.
- NCIT_C38996 label "ATM Signaling Pathway" @default.
- NCIT_C38996 subClassOf NCIT_C17132 @default.
- NCIT_C38996 subClassOf NCIT_C20633 @default.
- NCIT_C38996 subClassOf NCIT_C38996 @default.
- NCIT_C38996 subClassOf NCIT_C39705 @default.