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- NCIT_C38998 NCIT_NHC0 "C38998" @default.
- NCIT_C38998 NCIT_P106 "Functional Concept" @default.
- NCIT_C38998 NCIT_P108 "BAD Regulation Pathway" @default.
- NCIT_C38998 NCIT_P207 "C1516107" @default.
- NCIT_C38998 NCIT_P216 "h_badPathway" @default.
- NCIT_C38998 NCIT_P325 "The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112, 136, and 155). Phosphorylation at these sites results in loss of the ability of BAD to heterodimerize with the survival proteins BCL-XL or BCL-2. Phosphorylated BAD binds to 14-3-3 and is sequestered in the cytoplasm. While ser-136 phosphorylation is concordant with the activation of Akt, Ser-112 phosphorylation requires activation of the Ras-MAPK pathway. BAD Ser 155 was found to be a major site of phosphorylation induced following stimulation by growth factors and prevented by protein kinase A inhibitors. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C38998 NCIT_P366 "BAD_Regulation_Pathway" @default.
- NCIT_C38998 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C38998 normalizedInformationContent "75.111529024455209" @default.
- NCIT_C38998 referenceCount "43" @default.
- NCIT_C38998 hasExactSynonym "BAD Regulation Pathway" @default.
- NCIT_C38998 hasExactSynonym "Regulation of BAD phosphorylation" @default.
- NCIT_C38998 type Class @default.
- NCIT_C38998 isDefinedBy ncit.owl @default.
- NCIT_C38998 label "BAD Regulation Pathway" @default.
- NCIT_C38998 subClassOf NCIT_C19779 @default.
- NCIT_C38998 subClassOf NCIT_C20633 @default.
- NCIT_C38998 subClassOf NCIT_C38998 @default.