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- NCIT_C38999 NCIT_NHC0 "C38999" @default.
- NCIT_C38999 NCIT_P106 "Functional Concept" @default.
- NCIT_C38999 NCIT_P108 "BARD1 Pathway" @default.
- NCIT_C38999 NCIT_P207 "C1516117" @default.
- NCIT_C38999 NCIT_P216 "h_bard1Pathway" @default.
- NCIT_C38999 NCIT_P325 "BRCA1 is a breast and ovarian cancer tumor suppressor protein that associates with BARD1 to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an ubiquitin (Ub) ligase with activity substantially greater than individual BRCA1 or BARD1 subunits. The BRCA1 tumor suppressor forms a heterodimer with the BARD1 protein, and the resulting complex functions as an E3 ubiquitin ligase that catalyzes the synthesis of polyubiquitin chains. UbcH5c and UbcH7 also interact with the BRCA1/BARD1 complex with similar affinity (not shown on this figure). Although the in vivo substrate(s) is not yet known, BRCA1 has been observed to undergo autoubiquitination and is capable of monoubiquitinating histones 2A and 2AX in vitro. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C38999 NCIT_P366 "BARD1_Pathway" @default.
- NCIT_C38999 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C38999 normalizedInformationContent "80.873941456936294" @default.
- NCIT_C38999 referenceCount "18" @default.
- NCIT_C38999 hasExactSynonym "BARD1 Pathway" @default.
- NCIT_C38999 hasExactSynonym "BRCA1-dependent Ub-ligase activity" @default.
- NCIT_C38999 type Class @default.
- NCIT_C38999 isDefinedBy ncit.owl @default.
- NCIT_C38999 label "BARD1 Pathway" @default.
- NCIT_C38999 subClassOf NCIT_C20633 @default.
- NCIT_C38999 subClassOf NCIT_C38999 @default.
- NCIT_C38999 subClassOf NCIT_C39705 @default.