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- NCIT_C39003 NCIT_NHC0 "C39003" @default.
- NCIT_C39003 NCIT_P106 "Functional Concept" @default.
- NCIT_C39003 NCIT_P108 "Bystander B Cell Activation Pathway" @default.
- NCIT_C39003 NCIT_P207 "C1511352" @default.
- NCIT_C39003 NCIT_P216 "h_bbcellPathway" @default.
- NCIT_C39003 NCIT_P325 "Expression of Fas-Ligand by T cells can induce apoptosis through interaction with Fas on the target cell. A target of Fas-mediated apoptosis is the B cell. B cells that are not activated by antigen, bystander B cells, can interact through CD40 with the CD40 ligand on T cells. The CD40-CD40L interaction induces Fas expression by bystander B cells, and the interaction of Fas with the T cell Fas-Ligand, followed by B cell apoptosis. B cells that are activated by antigen binding and that interact with the T cell receptor through the B cell MHC II appear to become resistant to Fas-mediated apoptosis, survive and proliferate. IL-4 also appears to confer B cell resistance to Fas-mediated apoptosis. The induction of apoptosis in non-antigen stimulated B cells may prevent B cells from proliferating inappropriately and failure of this mechanism may be involved in autoimmune disorders and B cell lymphomas. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39003 NCIT_P366 "Bystander_B_Cell_Activation_Pathway" @default.
- NCIT_C39003 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39003 normalizedInformationContent "82.080392758357064" @default.
- NCIT_C39003 referenceCount "15" @default.
- NCIT_C39003 hasExactSynonym "Bystander B Cell Activation Pathway" @default.
- NCIT_C39003 hasExactSynonym "Bystander B Cell Activation" @default.
- NCIT_C39003 type Class @default.
- NCIT_C39003 isDefinedBy ncit.owl @default.
- NCIT_C39003 label "Bystander B Cell Activation Pathway" @default.
- NCIT_C39003 subClassOf NCIT_C19779 @default.
- NCIT_C39003 subClassOf NCIT_C20633 @default.
- NCIT_C39003 subClassOf NCIT_C39003 @default.
- NCIT_C39003 subClassOf NCIT_C39698 @default.