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- NCIT_C39017 NCIT_NHC0 "C39017" @default.
- NCIT_C39017 NCIT_P106 "Functional Concept" @default.
- NCIT_C39017 NCIT_P108 "CCR3 Signaling Pathway" @default.
- NCIT_C39017 NCIT_P207 "C1511415" @default.
- NCIT_C39017 NCIT_P216 "h_CCR3Pathway" @default.
- NCIT_C39017 NCIT_P325 "Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic reactions in skin and airway. The eosinophil response in inflammation is absent in mice lacking CCR3, indicating the key role of this G protein coupled receptor in inflammation and allergic responses. Eotaxin is a chemokine ligand for CCR3 that recruits eosinophils to the site of inflammation and activates them. Other chemokine ligands of CCR3 include eotaxin-2, MCP-3, MCP-4, and RANTES. Multiple signaling pathways activated by CCR3 participate in the inflammatory response of eosinophils. Eotaxin stimulates intracellular calcium release, production of reactive oxygen species, and changes in actin polymerization through a pertussis sensitive pathway. Rho is a G protein that activates ROCK, a protein kinase. Rho and ROCK regulate actin stress fiber formation and are required for eosinophil chemotaxis. Map kinase pathways are also involved in chemotaxis. Another key action of activated eosinophils is the release of reactive oxygen species, causing tissue damage during chronic inflammatory responses. Blocking eosinophil activation and the signaling pathways that lead to chemotaxis, degranulation, and reactive oxygen release may alleviate inflammatory conditions and inflammation-associated tissue damage. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39017 NCIT_P366 "CCR3_Signaling_Pathway" @default.
- NCIT_C39017 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39017 normalizedInformationContent "77.066663625307044" @default.
- NCIT_C39017 referenceCount "32" @default.
- NCIT_C39017 hasExactSynonym "CCR3 Signaling Pathway" @default.
- NCIT_C39017 hasExactSynonym "CCR3 signaling in Eosinophils" @default.
- NCIT_C39017 type Class @default.
- NCIT_C39017 isDefinedBy ncit.owl @default.
- NCIT_C39017 label "CCR3 Signaling Pathway" @default.
- NCIT_C39017 subClassOf NCIT_C17132 @default.
- NCIT_C39017 subClassOf NCIT_C20633 @default.
- NCIT_C39017 subClassOf NCIT_C39017 @default.