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- NCIT_C39022 NCIT_NHC0 "C39022" @default.
- NCIT_C39022 NCIT_P106 "Functional Concept" @default.
- NCIT_C39022 NCIT_P108 "MAP Kinase Downregulation Pathway" @default.
- NCIT_C39022 NCIT_P207 "C1518105" @default.
- NCIT_C39022 NCIT_P216 "h_cdk5Pathway" @default.
- NCIT_C39022 NCIT_P325 "Map kinases transduce responses to extracellular signals by a variety of routes, and communicate with other pathways through extensive crosstalk networks. A closely studied Map kinase cascade originates with tyrosine kinase activation, and activation of Ras. Ras activates Raf, Raf activates the Map kinase kinases Mek1 and Mek2 and these kinases activate downstream Map kinases like Erk1 and Erk2. Erk1 and Erk2 in turn activate transgenes like p35 through the Map kinase activated transcription factor EGR-1. Mek1 plays a central role in many different Map kinase pathways. Factors that activate Mek1 include growth factors like NGF, cytokines, chemokines, and phorbol ester, resulting in cellular proliferation and survival. Mek1 activation may also play a role in differentiation in neuronal tissues. In cultured neuronal PC-12 cells, NGF induces neurite outgrowth via Mek1 and the map kinase pathway. Constitutive activation of Mek1 can transform cells and may play a role in cancer. The crucial role of Mek1 in a variety of pathways including cellular transformation suggests that the cell must tightly regulate its activity. Cdk5 is a kinase that regulates the activity of Mek1. Although Cdk5 is a member of the cyclin-dependent kinase gene family, the activity of Cdk5 does not appear to be regulated by cyclins, but is activated by association with p35. Cdk5 does not act as a checkpoint kinase to regulate cell cycle progression, but acts as a regulatory kinase involved in other post-mitotic processes such as neuronal activity such as neuronal migration during development and neurite outgrowth. Mice lacking Cdk5 exhibit defects in neuronal development. One target of Cdk5 is Mek1. Phosphorylation of Mek1 by Cdk5 represses Mek1 activity and blocks downstream cellular responses. The activation of p35 by Map kinase pathways followed by deactivation of Map kinase signaling by the Cdk5/p35 complex completes the loop of a feedback circuit to terminate Map kinase signaling. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39022 NCIT_P366 "MAP_Kinase_Downregulation_Pathway" @default.
- NCIT_C39022 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39022 normalizedInformationContent "78.700176784839257" @default.
- NCIT_C39022 referenceCount "25" @default.
- NCIT_C39022 hasExactSynonym "MAP Kinase Downregulation Pathway" @default.
- NCIT_C39022 hasExactSynonym "Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway" @default.
- NCIT_C39022 type Class @default.
- NCIT_C39022 isDefinedBy ncit.owl @default.
- NCIT_C39022 label "MAP Kinase Downregulation Pathway" @default.
- NCIT_C39022 subClassOf NCIT_C19779 @default.
- NCIT_C39022 subClassOf NCIT_C20633 @default.
- NCIT_C39022 subClassOf NCIT_C39022 @default.