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- NCIT_C39024 NCIT_NHC0 "C39024" @default.
- NCIT_C39024 NCIT_P106 "Functional Concept" @default.
- NCIT_C39024 NCIT_P108 "Cell to Cell Adhesion Signaling Pathway" @default.
- NCIT_C39024 NCIT_P207 "C1516364" @default.
- NCIT_C39024 NCIT_P216 "h_cell2cellPathway" @default.
- NCIT_C39024 NCIT_P325 "Interactions between cells, responsible for cell to cell adhesion, can communicate signals into the cellular interior. These signals often involve interactions with cytoskeletal elements to produce changes in cell motility, migration, proliferation and shape. The cadherins are cell surface adhesion molecules that help form tight junctions between cells, such as in formation of epithelial cell layers. E-cadherin inactivation has been implicated in cancer development. In addition to mediating adhesion with other cells, cadherins transduce signals into cells through interactions with the catenins. Catenins probably affect actin cytoskeletal function through interactions with proteins such as actinin and vinculin. Catenins also probably trigger changes in cell shape and motility by signals through the Rho small GTPases. Another important cell adhesion molecule is CD-31, or PECAM-1, involved in the formation of junctions between endothelial cells, cell migration, migration of lymphocytes, and regulation of lymphocyte activation. Src phosphorylates PECAM-1 on tyrosine residues causing SHP-2 association with PECAM-1. Paxillin acts as an adaptor protein between proteins involved in adhesion signaling like FAK and src and cytoskeletal elements. In addition to signals created by adhesion molecules to alter cellular responses, other signaling pathways can alter adhesion through components of the focal adhesion complex. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39024 NCIT_P366 "Cell_to_Cell_Adhesion_Signaling_Pathway" @default.
- NCIT_C39024 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39024 normalizedInformationContent "79.251926409996102" @default.
- NCIT_C39024 referenceCount "23" @default.
- NCIT_C39024 hasExactSynonym "Cell to Cell Adhesion Signaling Pathway" @default.
- NCIT_C39024 hasExactSynonym "Cell to Cell Adhesion Signaling" @default.
- NCIT_C39024 type Class @default.
- NCIT_C39024 isDefinedBy ncit.owl @default.
- NCIT_C39024 label "Cell to Cell Adhesion Signaling Pathway" @default.
- NCIT_C39024 subClassOf NCIT_C17132 @default.
- NCIT_C39024 subClassOf NCIT_C20633 @default.
- NCIT_C39024 subClassOf NCIT_C39024 @default.