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- NCIT_C39035 NCIT_NHC0 "C39035" @default.
- NCIT_C39035 NCIT_P106 "Functional Concept" @default.
- NCIT_C39035 NCIT_P108 "Mitochondrial Carnitine Palmitoyltransferase Pathway" @default.
- NCIT_C39035 NCIT_P207 "C1513341" @default.
- NCIT_C39035 NCIT_P216 "h_cptPathway" @default.
- NCIT_C39035 NCIT_P325 "The oxidation of fatty acids is an important source of energy for ATP production in mitochondria through the entry of acetyl-CoA into the Krebs cycle. Fatty acids are oxidized inside the mitochondrial matrix but the fatty acids to be oxidized come from the cytosol. Fatty acids are activated in the cytosol by esterification with Coenzyme A (CoA) to form acyl-CoA (RCO-CoA, where R is the fatty acid acyl group). Activated medium-chain fatty acids (C8 and C10) freely diffuse into mitochondria to be oxidized but long chain fatty acids must be transported in. The transport of long chain fatty acids into mitochondria for oxidation is accomplished by the carnitine palmitoyltransferase system (CPTI and CPTII). CPTI exchanges carnitine for the CoA attached to long chain fatty acids to form a fatty acid-carnitine conjugate (RCO-carnitine). The fatty acid-carnitine is transported into the matrix by a transporter protein in the inner mitochondrial membrane. Once the fatty acid-carnitine is inside the matrix, CPTII exchanges CoA for carnitine to produce fatty acid-CoA once again, ready to enter fatty acid oxidation in the matrix to produce energy. The free carnitine is transported back out to renew the cytoplasmic pool of carnitine and allow the transfer process to continue. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39035 NCIT_P366 "Mitochondrial_Carnitine_Palmitoyltransferase_Pathway" @default.
- NCIT_C39035 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39035 normalizedInformationContent "100" @default.
- NCIT_C39035 referenceCount "1" @default.
- NCIT_C39035 hasExactSynonym "Mitochondrial Carnitine Palmitoyltransferase (CPT) System" @default.
- NCIT_C39035 hasExactSynonym "Mitochondrial Carnitine Palmitoyltransferase Pathway" @default.
- NCIT_C39035 type Class @default.
- NCIT_C39035 isDefinedBy ncit.owl @default.
- NCIT_C39035 label "Mitochondrial Carnitine Palmitoyltransferase Pathway" @default.
- NCIT_C39035 subClassOf NCIT_C18611 @default.
- NCIT_C39035 subClassOf NCIT_C20633 @default.
- NCIT_C39035 subClassOf NCIT_C39035 @default.