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- NCIT_C39036 NCIT_NHC0 "C39036" @default.
- NCIT_C39036 NCIT_P106 "Functional Concept" @default.
- NCIT_C39036 NCIT_P108 "CREB Activation Signaling Pathway" @default.
- NCIT_C39036 NCIT_P207 "C1511454" @default.
- NCIT_C39036 NCIT_P216 "h_crebPathway" @default.
- NCIT_C39036 NCIT_P325 "The transcription factor CREB binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Protein kinase A and the calmodulin-dependent protein kinases CaMKII stimulate CREB phosphorylation at Ser133, a key regulatory site controlling transcriptional activity. Growth and neurotrophic factors also stimulate CREB phosphorylation at Ser133. Phosphorylation occurs at Ser133 via p44/42 MAP Kinase and p90RSK and also via p38 MAP Kinase and MSK1. CREB mutants exhibit deficiencies in spatial learning tasks, while flies overexpressing or lacking CREB show enhanced or diminished learning, respectively. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39036 NCIT_P366 "CREB_Activation_Signaling_Pathway" @default.
- NCIT_C39036 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39036 normalizedInformationContent "75.929502612838462" @default.
- NCIT_C39036 referenceCount "38" @default.
- NCIT_C39036 hasExactSynonym "CREB Activation Signaling Pathway" @default.
- NCIT_C39036 hasExactSynonym "Transcription factor CREB and its extracellular signals" @default.
- NCIT_C39036 type Class @default.
- NCIT_C39036 isDefinedBy ncit.owl @default.
- NCIT_C39036 label "CREB Activation Signaling Pathway" @default.
- NCIT_C39036 subClassOf NCIT_C17132 @default.
- NCIT_C39036 subClassOf NCIT_C20633 @default.
- NCIT_C39036 subClassOf NCIT_C39036 @default.