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- NCIT_C39037 NCIT_NHC0 "C39037" @default.
- NCIT_C39037 NCIT_P106 "Functional Concept" @default.
- NCIT_C39037 NCIT_P108 "Spermatogenesis Regulation Pathway" @default.
- NCIT_C39037 NCIT_P207 "C1519448" @default.
- NCIT_C39037 NCIT_P216 "h_cremPathway" @default.
- NCIT_C39037 NCIT_P325 "The transcriptional regulator CREM plays a key role in spermatogenesis, acting as a central transcription factor triggering a cascade of transcriptional activation of post-meiotic genes involved in this process such as calspermin and testis angiotensin-converting enzyme. The key role of CREM in sperm formation is demonstrated by the male sterility of mice lacking CREM, the failure of spermatids to develop into mature sperm, and a lack of post-meiotic gene expression in these animals. Prior to meiosis, splice variants of CREM act as antagonists of cAMP-dependent transcriptional activation, but coordinate with spermatogenesis, the potent transcriptional activator CREM tau splice variant is highly expressed. In other tissues CREM activates genes in response to cAMP through phosphorylation and CBP association, but transcriptional activation by CREM in male germ cells is CBP independent. Stimulation of spermatids with follicle-stimulating hormone (FSH) induces cAMP formation, and the association of CREM with the coactivator ACT, although the mechanism regulating the interaction of CREM with ACT is not yet known. A two-hybrid screen looking for ACT interacting factors revealed another surprising component regulating CREM, the kinesin Kif17b. Kinesins are molecular motors that interact with microtubules to transport organelles and other material within the cell. Kif17b is actively exported from the nucleus in a Crm1-dependent manner, so when it is bound to ACT the export of Kif17b excludes CREM-ACT from the nucleus and blocks transcriptional activation by this complex. The mechanism regulating the interaction of Kif17b with ACT to drive CREM activation is not yet known. Although the regulation of transcription by a kinesin is surprising, a functional connection between cytoskeletal elements and transcriptional regulation is not unprecedented, as demonstrated by the transcription factor MIZ-1 that regulates transcription in response to changes in microtubule structure. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39037 NCIT_P366 "Spermatogenesis_Regulation_Pathway" @default.
- NCIT_C39037 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39037 normalizedInformationContent "83.556969816060246" @default.
- NCIT_C39037 referenceCount "12" @default.
- NCIT_C39037 hasExactSynonym "Regulation of Spermatogenesis by CREM" @default.
- NCIT_C39037 hasExactSynonym "Spermatogenesis Regulation Pathway" @default.
- NCIT_C39037 type Class @default.
- NCIT_C39037 isDefinedBy ncit.owl @default.
- NCIT_C39037 label "Spermatogenesis Regulation Pathway" @default.
- NCIT_C39037 subClassOf NCIT_C19779 @default.
- NCIT_C39037 subClassOf NCIT_C20633 @default.
- NCIT_C39037 subClassOf NCIT_C39037 @default.