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- NCIT_C39040 NCIT_NHC0 "C39040" @default.
- NCIT_C39040 NCIT_P106 "Functional Concept" @default.
- NCIT_C39040 NCIT_P108 "CTCF Pathway" @default.
- NCIT_C39040 NCIT_P207 "C1511458" @default.
- NCIT_C39040 NCIT_P216 "h_ctcfPathway" @default.
- NCIT_C39040 NCIT_P325 "CTCF is central to signaling pathways in immature B cells elicited by cross-linking the Ig BCR and stimulation with TGF. Both stimuli result in induction of cell cycle arrest and apoptosis. BCR ligation stimulates a transient induction of MYC that leads to high level CTCF expression and feedback suppression of MYC transcription. BCR ligation also activates PTEN opposing PI3K activation of MYC. Pharmacologic inactivation of PI3K or mTOR/FRAP results in suppression of S6K resulting in activation of CTCF and suppression of MYC. CTCF activation induces transcriptional activation of p19ARF, with its downstream consequences, and of p27. Growth arrest is occasioned by co-expression of p21 and p27 and inhibition of MYC. CTCF, is a multivalent DNA-sequence binder whose specificity is mediated by different sets of zinc finger (ZF) proteins. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39040 NCIT_P366 "CTCF_Pathway" @default.
- NCIT_C39040 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39040 normalizedInformationContent "75.267234140859458" @default.
- NCIT_C39040 referenceCount "42" @default.
- NCIT_C39040 hasExactSynonym "CTCF Pathway" @default.
- NCIT_C39040 hasExactSynonym "CTCF: First Multivalent Nuclear Factor" @default.
- NCIT_C39040 type Class @default.
- NCIT_C39040 isDefinedBy ncit.owl @default.
- NCIT_C39040 label "CTCF Pathway" @default.
- NCIT_C39040 subClassOf NCIT_C19779 @default.
- NCIT_C39040 subClassOf NCIT_C20633 @default.
- NCIT_C39040 subClassOf NCIT_C39040 @default.