Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C39041> ?p ?o ?g. }
Showing items 1 to 20 of
20
with 100 items per page.
- NCIT_C39041 NCIT_NHC0 "C39041" @default.
- NCIT_C39041 NCIT_P106 "Functional Concept" @default.
- NCIT_C39041 NCIT_P108 "T-Cell Activation Co-Stimulatory Signaling Pathway" @default.
- NCIT_C39041 NCIT_P207 "C1515121" @default.
- NCIT_C39041 NCIT_P216 "h_ctla4Pathway" @default.
- NCIT_C39041 NCIT_P325 "For a T cell to be activated by a specific antigen, the T cell receptor must recognize complexes of MHC-1 with the antigen on the surface of an antigen-presenting cell. T cells and the T cell receptor complex do not respond to antigen in solution, but even for the specific antigen they only respond to antigen-MHC-1 complexes on the cell surface. This interaction is necessary for T cell activation, but it is not sufficient. T cell activation also requires a co-stimulatory signal involving interaction of CD28 on the T cell with CD80 or CD86 (B7 family genes) on the antigen-presenting cell. CD28 activates a signal transduction pathway acting through PI-3K, Lck and Grb-2/ITK to provide its co-stimulatory signal for T cell activation. Another means to control T cell activation is by expressing factors that down-regulate T cell activation. Signaling by activated T cell receptors induces expression of CTLA-4, a receptor that opposes T cell activation. CTLA-4 has a higher affinity than CD28 for B7 proteins, terminating T cell activation. ICOS is a protein related to CD28 that is only expressed on activated T cells, and that provides another important co-stimulatory signal. The requirement for co-stimulatory signals provides additional control mechanisms that prevent inappropriate and hazardous T cell activation. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39041 NCIT_P366 "T-Cell_Activation_Co-Stimulatory_Signaling_Pathway" @default.
- NCIT_C39041 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39041 normalizedInformationContent "76.105970727550996" @default.
- NCIT_C39041 referenceCount "37" @default.
- NCIT_C39041 hasExactSynonym "T-Cell Activation Co-Stimulatory Signaling Pathway" @default.
- NCIT_C39041 hasExactSynonym "The Co-Stimulatory Signal During T-cell Activation" @default.
- NCIT_C39041 type Class @default.
- NCIT_C39041 isDefinedBy ncit.owl @default.
- NCIT_C39041 label "T-Cell Activation Co-Stimulatory Signaling Pathway" @default.
- NCIT_C39041 subClassOf NCIT_C17132 @default.
- NCIT_C39041 subClassOf NCIT_C19779 @default.
- NCIT_C39041 subClassOf NCIT_C20633 @default.
- NCIT_C39041 subClassOf NCIT_C39041 @default.
- NCIT_C39041 subClassOf NCIT_C39698 @default.