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- NCIT_C39049 NCIT_NHC0 "C39049" @default.
- NCIT_C39049 NCIT_P106 "Functional Concept" @default.
- NCIT_C39049 NCIT_P108 "DR3 and DR4/5 Mediated Apoptosis Pathway" @default.
- NCIT_C39049 NCIT_P207 "C1511707" @default.
- NCIT_C39049 NCIT_P216 "h_deathPathway" @default.
- NCIT_C39049 NCIT_P325 "Apoptosis is specifically induced via signaling through a family of receptors known collectively as 'death receptors' including Fas, TNFR, DR3, -4 and -5. Death receptor ligands characteristically initiate signaling via receptor oligomerization, recruitment of specialized adaptor proteins and activation of caspase cascades. Apo3L recruits initiator caspase 8 via the adapter protein FADD. Caspase 8 then oligomerizes and is activated via autocatalysis. Activated caspase 8 stimulates apoptosis via two parallel cascades: it directly cleaves and activates caspase-3, and it cleaves Bid (a Bcl-2 family protein). Truncated Bid (tBid) translocates to mitochondria, inducing cytochrome C release, which sequentially activates caspases 9 and 3. DR-3L can deliver pro- or anti-apoptotic signals. DR-3 promotes apoptosis via the adaptor proteins TRADD/FADD and the activation of caspase 8. Alternatively, apoptosis is inhibited via an adaptor protein complex including RIP which activates NF-kB and induces survival genes including IAP. Induction of apoptosis via Apo2L requires caspase activity, but the adaptor requirement is unclear. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39049 NCIT_P366 "DR3_and_DR4_5_Mediated_Apoptosis_Pathway" @default.
- NCIT_C39049 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39049 normalizedInformationContent "73.982472314446994" @default.
- NCIT_C39049 referenceCount "51" @default.
- NCIT_C39049 hasExactSynonym "DR3 and DR4/5 Mediated Apoptosis Pathway" @default.
- NCIT_C39049 hasExactSynonym "Induction of apoptosis through DR3 and DR4/5 Death Receptors" @default.
- NCIT_C39049 type Class @default.
- NCIT_C39049 isDefinedBy ncit.owl @default.
- NCIT_C39049 label "DR3 and DR4/5 Mediated Apoptosis Pathway" @default.
- NCIT_C39049 subClassOf NCIT_C19779 @default.
- NCIT_C39049 subClassOf NCIT_C20633 @default.
- NCIT_C39049 subClassOf NCIT_C39049 @default.
- NCIT_C39049 subClassOf NCIT_C39699 @default.