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- NCIT_C39051 NCIT_NHC0 "C39051" @default.
- NCIT_C39051 NCIT_P106 "Functional Concept" @default.
- NCIT_C39051 NCIT_P108 "Apoptotic DNA Fragmentation Pathway" @default.
- NCIT_C39051 NCIT_P207 "C1516045" @default.
- NCIT_C39051 NCIT_P216 "h_DNAfragmentPathway" @default.
- NCIT_C39051 NCIT_P325 "Apoptotic cell death can be triggered by many different cellular stimuli, resulting in activation of apoptotic signaling pathways including caspases and mitochondria. A cellular response that is characteristic of apoptosis is fragmentation of the nuclear genome to create a nucleosomal ladder. This activity is conducted by multiple nucleases activated by apoptotic signaling pathways. One nuclease involved in apoptosis is DNA fragmentation factor (DFF), a caspase-activated DNAse (CAD). DFF/CAD is activated through cleavage of its associated inhibitor ICAD by caspases proteases during apoptosis. DFF/CAD interacts with chromatin components such as topo II and histone H1 to condense chromatin structure and perhaps recruit CAD to chromatin. Another apoptosis activated protease is endonuclease G, EndoG. EndoG is encoded in the nuclear genome but is localized to mitochondria in normal cells. EndoG may play a role in the replication of the mitochondrial genome, as well as in apoptosis. Apoptotic signaling causes the release of EndoG from mitochondria. Mitochondria are involved in apoptotic signaling in other ways as well, through the release of cytochrome c induced by Bid to activate the caspase protease cascade. These pathways are independent since the EndoG pathway still occurs in cells lacking DFF. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39051 NCIT_P366 "Apoptotic_DNA_Fragmentation_Pathway" @default.
- NCIT_C39051 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39051 normalizedInformationContent "82.080392758357064" @default.
- NCIT_C39051 referenceCount "15" @default.
- NCIT_C39051 hasExactSynonym "Apoptotic DNA Fragmentation Pathway" @default.
- NCIT_C39051 hasExactSynonym "Apoptotic DNA fragmentation and tissue homeostasis" @default.
- NCIT_C39051 type Class @default.
- NCIT_C39051 isDefinedBy ncit.owl @default.
- NCIT_C39051 label "Apoptotic DNA Fragmentation Pathway" @default.
- NCIT_C39051 subClassOf NCIT_C19779 @default.
- NCIT_C39051 subClassOf NCIT_C20633 @default.
- NCIT_C39051 subClassOf NCIT_C39051 @default.
- NCIT_C39051 subClassOf NCIT_C39699 @default.