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- NCIT_C39055 NCIT_NHC0 "C39055" @default.
- NCIT_C39055 NCIT_P106 "Functional Concept" @default.
- NCIT_C39055 NCIT_P108 "Phospholipid Signaling Pathway" @default.
- NCIT_C39055 NCIT_P207 "C1519058" @default.
- NCIT_C39055 NCIT_P216 "h_edg1Pathway" @default.
- NCIT_C39055 NCIT_P325 "Sphingosine-1-phosphate (S1P) is an example of a lipid messenger with both intracellular and extracellular functions. Intracellularly S1P regulates proliferation and survival; extracellularly S1P is a ligand for EDG1 (also known as S1P1). Activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine, increases cellular levels of S1P. Inhibitors of SPHK block formation of S1P and inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (PDGF) and PMA. In a study using endothelial cells it was demonstrated that S1P induces activation of alpha-v and B3 integrins via RhoA. S1P also activates Akt via Gi and PI3K. The activated Akt phosphorylates the Edg1 receptor on threonine 236 leading to the activation of Rac1 and subsequent signals leading to actin assembly, chemotaxis and lamellipodia formation. Edg1 stimulation also leads to the activation of the ERK signaling cascade resulting in anti-apoptotic reversal, proliferation and cell survival. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39055 NCIT_P366 "Phospholipid_Signaling_Pathway" @default.
- NCIT_C39055 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39055 normalizedInformationContent "74.665259135057511" @default.
- NCIT_C39055 referenceCount "46" @default.
- NCIT_C39055 hasExactSynonym "Phospholipid Signaling Pathway" @default.
- NCIT_C39055 hasExactSynonym "Phospholipids as signaling intermediaries" @default.
- NCIT_C39055 type Class @default.
- NCIT_C39055 isDefinedBy ncit.owl @default.
- NCIT_C39055 label "Phospholipid Signaling Pathway" @default.
- NCIT_C39055 subClassOf NCIT_C17132 @default.
- NCIT_C39055 subClassOf NCIT_C20633 @default.
- NCIT_C39055 subClassOf NCIT_C39055 @default.