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- NCIT_C39061 NCIT_NHC0 "C39061" @default.
- NCIT_C39061 NCIT_P106 "Functional Concept" @default.
- NCIT_C39061 NCIT_P108 "eIF2 Regulation Pathway" @default.
- NCIT_C39061 NCIT_P207 "C1515619" @default.
- NCIT_C39061 NCIT_P216 "h_eif2Pathway" @default.
- NCIT_C39061 NCIT_P325 "Protein phosphorylation plays an important role in the control of translation by eukaryotic initiation factor-2 (eIF-2). eIF-2 binds GTP and Met-tRNAi and transfers the Met-tRNA to the 40S subunit, to form the 43S preinitiation complex. Later in the cycle, prior to elongation, the bound GTP is hydrolyzed, releasing eIF-2-GDP. For eIF-2 to promote another round of initiation, GDP must be exchanged for GTP, a reaction catalyzed by eIF-2B. Kinases activated by viral infection (PKR), endoplasmic reticulum stress (PERK/PEK), amino acid deprivation (GCN2), and hemin deficiency (HRI) can phosphorylate the a subunit of eIF-2. This phosphorylation stabilizes the eIF-2-GDP-eIF-2B complex, inhibiting the turnover of eIF-2B. eIF-2B is also inhibited by GSK-3b phosphorylation. These events result in a shut-down of cellular protein synthesis and can lead to apoptosis. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39061 NCIT_P366 "eIF2_Regulation_Pathway" @default.
- NCIT_C39061 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39061 normalizedInformationContent "81.252167948509552" @default.
- NCIT_C39061 referenceCount "17" @default.
- NCIT_C39061 hasExactSynonym "Regulation of eIF2" @default.
- NCIT_C39061 hasExactSynonym "eIF2 Regulation Pathway" @default.
- NCIT_C39061 type Class @default.
- NCIT_C39061 isDefinedBy ncit.owl @default.
- NCIT_C39061 label "eIF2 Regulation Pathway" @default.
- NCIT_C39061 subClassOf NCIT_C19779 @default.
- NCIT_C39061 subClassOf NCIT_C20633 @default.
- NCIT_C39061 subClassOf NCIT_C39061 @default.