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- NCIT_C39072 NCIT_NHC0 "C39072" @default.
- NCIT_C39072 NCIT_P106 "Functional Concept" @default.
- NCIT_C39072 NCIT_P108 "Erk1/Erk2 MAPK Signaling Pathway" @default.
- NCIT_C39072 NCIT_P207 "C1516956" @default.
- NCIT_C39072 NCIT_P216 "h_erkPathway" @default.
- NCIT_C39072 NCIT_P325 "The p44/42 MAP Kinase pathway consists of a protein kinase cascade linking growth and differentiation signals with transcription in the nucleus. Growth factor receptors and tyrosine kinases activate Ras which in turn activates c-Raf, MEK, and MAP kinase. Activated p44/42 MAP Kinase translocates to the nucleus and activates transcription by phosphorylation of kinases such as p90 RSK, MSK, and transcription factors such as ELK-1 and Stat3. The importance of this pathway in both growth control and development has been demonstrated via the transforming properties of various mutant forms of Ras, Raf, and MEK and by their effects on development. Signal amplification and the potential for crosstalk appear to be important features of this regulatory network. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39072 NCIT_P366 "Erk1_Erk2_MAPK_Signaling_Pathway" @default.
- NCIT_C39072 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39072 normalizedInformationContent "74.113509509900666" @default.
- NCIT_C39072 referenceCount "50" @default.
- NCIT_C39072 hasExactSynonym "Erk1/Erk2 MAPK Signaling Pathway" @default.
- NCIT_C39072 hasExactSynonym "Erk1/Erk2 Mapk Signaling pathway" @default.
- NCIT_C39072 type Class @default.
- NCIT_C39072 isDefinedBy ncit.owl @default.
- NCIT_C39072 label "Erk1/Erk2 MAPK Signaling Pathway" @default.
- NCIT_C39072 subClassOf NCIT_C17132 @default.
- NCIT_C39072 subClassOf NCIT_C20633 @default.
- NCIT_C39072 subClassOf NCIT_C39072 @default.