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- NCIT_C39077 NCIT_NHC0 "C39077" @default.
- NCIT_C39077 NCIT_P106 "Functional Concept" @default.
- NCIT_C39077 NCIT_P108 "Fas Signaling Pathway BioCarta" @default.
- NCIT_C39077 NCIT_P207 "C1517135" @default.
- NCIT_C39077 NCIT_P216 "h_fasPathway" @default.
- NCIT_C39077 NCIT_P325 "Receptors in the TNF receptor family are associated with the induction of apoptosis, as well as inflammatory signaling. The Fas receptor (CD95) mediates apoptotic signaling by Fas-ligand expressed on the surface of other cells. The Fas-FasL interaction plays an important role in the immune system and lack of this system leads to autoimmunity, indicating that Fas-mediated apoptosis removes self-reactive lymphocytes. Fas signaling is also involved in immune surveillance to remove transformed cells and virus infected cells. Binding of FAS to oligomerized FasL on another cell activates apoptotic signaling through a cytoplasmic domain termed the death domain that interacts with signaling adaptors including FAF, FADD and DAX to activate the caspase proteolytic cascade. Caspase-8 and caspase-10 are first activated and then cleave and activate downstream caspases, and a variety of cellular substrates, leading to cell death. Caspases cleave nuclear lamins, causing the nucleus to break down and lose its normal structure. They also cleave DFF, inducing cleavage and degradation of the genome. Other caspase substrates are involved in cytoskeletal structure, cell cycle regulation and signaling pathways. Activation of JNK kinase, activation of Jun, and production of ceramide may also play roles in Fas-mediated apoptosis. Activation of Fas-mediated apoptosis is opposed by I-FLICE and FAP. Viruses and tumors may escape immune surveillance in part through suppression of Fas-mediated apoptosis. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39077 NCIT_P366 "Fas_Signaling_Pathway" @default.
- NCIT_C39077 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39077 normalizedInformationContent "73.982472314446994" @default.
- NCIT_C39077 referenceCount "51" @default.
- NCIT_C39077 hasExactSynonym "FAS signaling pathway ( CD95 )" @default.
- NCIT_C39077 hasExactSynonym "Fas Signaling Pathway BioCarta" @default.
- NCIT_C39077 type Class @default.
- NCIT_C39077 isDefinedBy ncit.owl @default.
- NCIT_C39077 label "Fas Signaling Pathway BioCarta" @default.
- NCIT_C39077 subClassOf NCIT_C17132 @default.
- NCIT_C39077 subClassOf NCIT_C19779 @default.
- NCIT_C39077 subClassOf NCIT_C20633 @default.
- NCIT_C39077 subClassOf NCIT_C39077 @default.
- NCIT_C39077 subClassOf NCIT_C39699 @default.