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- NCIT_C39084 NCIT_NHC0 "C39084" @default.
- NCIT_C39084 NCIT_P106 "Functional Concept" @default.
- NCIT_C39084 NCIT_P108 "Free Radical Induced Apoptosis Pathway" @default.
- NCIT_C39084 NCIT_P207 "C1517313" @default.
- NCIT_C39084 NCIT_P216 "h_freePathway" @default.
- NCIT_C39084 NCIT_P325 "Oxidative stress is one factor that can trigger programmed cell death. Activated neutrophils responding to inflammatory stimulation produce reactive oxygen species like superoxide free radicals to kill invading bacteria, but these reactive oxygen species can also attack endothelial cells lining the vascular wall and trigger apoptosis. Endothelial cells also produce reactive oxygen species inside the cell that can contribute to oxidative stress and apoptosis, such as during reperfusion injury following ischemia. Superoxide dismutase (SOD) converts highly reactive and damaging superoxide free radicals to peroxides that are less reactive than superoxide but stimulate apoptosis. The glutathione (GSH) peptide reducing agent removes toxic metabolites and repairs damage created by reactive oxygen species. Glutathione peroxidase (GPx), for example, removes peroxides using glutathione as a reducing agent, and glutathione reductase (GSR) regenerates reduced glutathione. Inside the endothelial cell peroxide can be converted to hydroxyl ions in the presence of iron. Peroxides and hydroxyl radicals activate NF-kB and activate expression of inflammatory genes including adhesion molecules, TNF and IL-8. The apoptotic response of endothelial cells to oxidative stress may be involved in the development and progression of atherosclerosis. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39084 NCIT_P366 "Free_Radical_Induced_Apoptosis_Pathway" @default.
- NCIT_C39084 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39084 normalizedInformationContent "85.460608731874885" @default.
- NCIT_C39084 referenceCount "9" @default.
- NCIT_C39084 hasExactSynonym "Free Radical Induced Apoptosis Pathway" @default.
- NCIT_C39084 hasExactSynonym "Free Radical Induced Apoptosis" @default.
- NCIT_C39084 type Class @default.
- NCIT_C39084 isDefinedBy ncit.owl @default.
- NCIT_C39084 label "Free Radical Induced Apoptosis Pathway" @default.
- NCIT_C39084 subClassOf NCIT_C19779 @default.
- NCIT_C39084 subClassOf NCIT_C20633 @default.
- NCIT_C39084 subClassOf NCIT_C39084 @default.
- NCIT_C39084 subClassOf NCIT_C39699 @default.