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- NCIT_C39086 NCIT_NHC0 "C39086" @default.
- NCIT_C39086 NCIT_P106 "Functional Concept" @default.
- NCIT_C39086 NCIT_P108 "G1/S Checkpoint Pathway" @default.
- NCIT_C39086 NCIT_P207 "C1517343" @default.
- NCIT_C39086 NCIT_P216 "h_g1Pathway" @default.
- NCIT_C39086 NCIT_P325 "The G1/S cell cycle checkpoint controls the passage of eukaryotic cells from the first 'gap' phase (G1) into the DNA synthesis phase (S). Two cell cycle kinases, CDK4/6-cyclin D and CDK2-cyclin E, and the transcription complex that includes Rb and E2F are pivotal in controlling this checkpoint. During G1 phase, the Rb-HDAC repressor complex binds to the E2F-DP1 transcription factors, inhibiting downstream transcription. Phosphorylation of Rb by CDK4/6 and CDK2 dissociates the Rb-repressor complex, permitting transcription of S-phase genes encoding for proteins that amplify the G1 to S phase switch and that are required for DNA replication. Many different stimuli exert checkpoint control including TGFb, DNA damage, contact inhibition, replicative senescence, and growth factor withdrawal. The first four act by inducing members of the INK4 or Kip/Cip families of cell cycle kinase inhibitors. TGFb additionally inhibits the transcription of Cdc25A, a phosphatase that activates the cell cycle kinases. Growth factor withdrawal activates GSK3b, which phosphorylates cyclin D, leading to its rapid ubiquitination and proteasomal degradation. Ubiquitination, nuclear export, and degradation are mechanisms commonly used to rapidly reduce the concentration of cell-cycle control proteins. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39086 NCIT_P366 "G1_S_Checkpoint_Pathway" @default.
- NCIT_C39086 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39086 normalizedInformationContent "73.982472314446994" @default.
- NCIT_C39086 referenceCount "51" @default.
- NCIT_C39086 hasExactSynonym "Cell Cycle: G1/S Check Point" @default.
- NCIT_C39086 hasExactSynonym "G1/S Checkpoint Pathway" @default.
- NCIT_C39086 type Class @default.
- NCIT_C39086 isDefinedBy ncit.owl @default.
- NCIT_C39086 label "G1/S Checkpoint Pathway" @default.
- NCIT_C39086 subClassOf NCIT_C19779 @default.
- NCIT_C39086 subClassOf NCIT_C20633 @default.
- NCIT_C39086 subClassOf NCIT_C39086 @default.
- NCIT_C39086 subClassOf NCIT_C39700 @default.