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- NCIT_C39087 NCIT_NHC0 "C39087" @default.
- NCIT_C39087 NCIT_P106 "Functional Concept" @default.
- NCIT_C39087 NCIT_P108 "Leloir Pathway of Galactose Metabolism" @default.
- NCIT_C39087 NCIT_P207 "C1517767" @default.
- NCIT_C39087 NCIT_P216 "h_g1pPathway" @default.
- NCIT_C39087 NCIT_P325 "Galactose is a hexose sugar found in the disaccharide lactose. Galactose has six carbons like glucose and differs from glucose only in the stereochemistry of one carbon, C4. The enzymes of carbohydrate metabolism are specific enough that galactose must be changed to glucose before it can enter glycolysis. To convert galactose to glucose, it is first phosphorylated by galactokinase to produce galactose-1-phosphate. Galactose is then exchanged with the glucose group in UDP-glucose to create UDP-galactose and release glucose-1-phosphate. An epimerase enzyme changes the stereochemistry of C4 in UDP-galactose, creating UDP-glucose. In the next round of the transfer reaction, this glucose is released as glucose-1-phosphate. Once released, glucose-1-phosphate is converted to glucose-6-phosphate and can enter glycolysis to generate energy. Mutation of the kinase, the transferase or the epimerase can result in clinical deficiencies in galactose metabolism known as galactosemias. Galactosemias range in severity depending on the nature of the genetic change, and are usually treated through avoidance of galactose in the diet, primarily from lactose in dairy products. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39087 NCIT_P366 "Leloir_Pathway_of_Galactose_Metabolism" @default.
- NCIT_C39087 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39087 normalizedInformationContent "100" @default.
- NCIT_C39087 referenceCount "1" @default.
- NCIT_C39087 hasExactSynonym "Leloir Pathway of Galactose Metabolism" @default.
- NCIT_C39087 hasExactSynonym "Leloir pathway of galactose metabolism" @default.
- NCIT_C39087 type Class @default.
- NCIT_C39087 isDefinedBy ncit.owl @default.
- NCIT_C39087 label "Leloir Pathway of Galactose Metabolism" @default.
- NCIT_C39087 subClassOf NCIT_C18611 @default.
- NCIT_C39087 subClassOf NCIT_C20633 @default.
- NCIT_C39087 subClassOf NCIT_C39087 @default.
- NCIT_C39087 subClassOf NCIT_C39726 @default.