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- NCIT_C39090 NCIT_NHC0 "C39090" @default.
- NCIT_C39090 NCIT_P106 "Functional Concept" @default.
- NCIT_C39090 NCIT_P108 "Th2 Cytokine Gene Induction Pathway" @default.
- NCIT_C39090 NCIT_P207 "C1515340" @default.
- NCIT_C39090 NCIT_P216 "h_GATA3pathway" @default.
- NCIT_C39090 NCIT_P325 "CD4+ helper T cells differentiate into distinct subtypes, Th1 and Th2. Th2 cells are involved in the response to extracellular helminth parasites and allergic responses and secrete a distinct set of cytokines including IL-4, IL-5 and IL-13. The development and differentiation of T cells is influenced by many factors, including transcription factors such as GATA-3, a transcription factor associated with induction of Th2 cells. Factors that increase cAMP levels in Th2 cells activate p38 kinase, which phosphorylates and activates GATA-3 independently of PKA. Cells expressing GATA-3 develop the profile of Th2 cells, secreting IL-4, IL-5 and IL-13. These cytokines are found in a gene cluster together and are regulated coordinately by GATA-3. Binding of GATA-3 in the regulatory regions of these genes alters chromatin structure, increasing accessibility to other transcription factors. Activation of the T cell receptor through interaction with antigen on antigen presenting cells activates NFAT and other transcription factors that cooperate with GATA-3 in inducing Th2 cell differentiation. Dominant negative GATA-3 can repress the secretion of these cytokines and block the airway inflammation that causes asthma. Blocking GATA-3 action such as through antisense treatment has been suggested as a therapeutic strategy to treat asthma. GATA-3 has also been implicated in developmental processes such as the development of the inner ear. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39090 NCIT_P366 "Th2_Cytokine_Gene_Induction_Pathway" @default.
- NCIT_C39090 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39090 normalizedInformationContent "78.44064696698068" @default.
- NCIT_C39090 referenceCount "26" @default.
- NCIT_C39090 hasExactSynonym "GATA3 participate in activating the Th2 cytokine genes expression" @default.
- NCIT_C39090 hasExactSynonym "Th2 Cytokine Gene Induction Pathway" @default.
- NCIT_C39090 type Class @default.
- NCIT_C39090 isDefinedBy ncit.owl @default.
- NCIT_C39090 label "Th2 Cytokine Gene Induction Pathway" @default.
- NCIT_C39090 subClassOf NCIT_C19779 @default.
- NCIT_C39090 subClassOf NCIT_C20633 @default.
- NCIT_C39090 subClassOf NCIT_C39090 @default.