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- NCIT_C39092 NCIT_NHC0 "C39092" @default.
- NCIT_C39092 NCIT_P106 "Functional Concept" @default.
- NCIT_C39092 NCIT_P108 "Growth Hormone Signaling Pathway" @default.
- NCIT_C39092 NCIT_P207 "C1512283" @default.
- NCIT_C39092 NCIT_P216 "h_ghPathway" @default.
- NCIT_C39092 NCIT_P325 "Growth hormone plays a major role in regulating growth during childhood and adolescence and also regulates metabolism. Defects in growth hormone signaling can result in dwarfism and decreases in growth hormone levels with age have been suggested to play a role in the reduced function of some physiological systems. Growth hormone signals a response in cells through the growth hormone receptor, a member of the cytokine receptor gene family. Growth hormone causes the receptor to dimerize, activating the JAK2 protein kinase. The activity of JAK2 mediates many of the downstream responses to growth hormone through phosphorylation of STAT transcription factors, MAP kinases, other kinase cascades and molecules involved in metabolism like IRS-1. Factors like SOCS and SHP-1 appear to play a role in the down regulation of signaling by growth hormone and cytokines. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39092 NCIT_P366 "Growth_Hormone_Signaling_Pathway" @default.
- NCIT_C39092 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39092 normalizedInformationContent "73.853979692042088" @default.
- NCIT_C39092 referenceCount "52" @default.
- NCIT_C39092 hasExactSynonym "Growth Hormone Signaling Pathway" @default.
- NCIT_C39092 type Class @default.
- NCIT_C39092 isDefinedBy ncit.owl @default.
- NCIT_C39092 label "Growth Hormone Signaling Pathway" @default.
- NCIT_C39092 subClassOf NCIT_C17132 @default.
- NCIT_C39092 subClassOf NCIT_C20633 @default.
- NCIT_C39092 subClassOf NCIT_C39092 @default.