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- NCIT_C39096 NCIT_NHC0 "C39096" @default.
- NCIT_C39096 NCIT_P106 "Functional Concept" @default.
- NCIT_C39096 NCIT_P108 "G-Protein Signaling Pathway" @default.
- NCIT_C39096 NCIT_P207 "C1517335" @default.
- NCIT_C39096 NCIT_P216 "h_gpcrPathway" @default.
- NCIT_C39096 NCIT_P325 "G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cAMP formation. The bg subunits from Gai and other G proteins are able to activate the MAP kinase pathways and PLCb. GPCRs coupled to the Gaq family of G proteins stimulate PLCb, which cleaves membrane phospholipids to produce IP3, which mobilizes intracellular calcium, and DAG, which activates PKC. Second messenger pathways then activate a range of effector systems to change cell behavior; in many cases this includes the regulation of gene transcription. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39096 NCIT_P366 "G-Protein_Signaling_Pathway" @default.
- NCIT_C39096 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39096 normalizedInformationContent "74.665259135057511" @default.
- NCIT_C39096 referenceCount "46" @default.
- NCIT_C39096 hasExactSynonym "G-Protein Signaling Pathway" @default.
- NCIT_C39096 hasExactSynonym "Signaling Pathway from G-Protein Families" @default.
- NCIT_C39096 type Class @default.
- NCIT_C39096 isDefinedBy ncit.owl @default.
- NCIT_C39096 label "G-Protein Signaling Pathway" @default.
- NCIT_C39096 subClassOf NCIT_C17132 @default.
- NCIT_C39096 subClassOf NCIT_C20633 @default.
- NCIT_C39096 subClassOf NCIT_C39096 @default.