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- NCIT_C39097 NCIT_NHC0 "C39097" @default.
- NCIT_C39097 NCIT_P106 "Functional Concept" @default.
- NCIT_C39097 NCIT_P108 "Granulocyte Adhesion Pathway" @default.
- NCIT_C39097 NCIT_P207 "C1512270" @default.
- NCIT_C39097 NCIT_P216 "h_granulocytesPathway" @default.
- NCIT_C39097 NCIT_P325 "Cell adhesion is a fundamental feature of multicellular organisms including their defense mechanisms. In the later case in mammals, leukocytes play central role. They bind bacteria, parasites, viruses, tumor cells etc. Furthermore, their interactions with the endothelium are of special importance. During an inflammation or immune reaction, specialized leukocytes (eosinophilic granulocytes) adhere to and pass through the endothelium of the blood vessels and the underlying matrix. The reaction passes through the following steps: 1. Rolling (the flow of cells is slowed down by first making contacts to the endothelium via P-, E-, and L-selectins and their receptors); 2. Adhesion (After activation of leukocyte integrins, firm contacts are established between them and endothelium molecules of the Ig superfamily - LFA-1, Mac-1, VLA-4 etc.); 3. Flattening of the cells and diapedesis (Adhering leukocytes crawl to an intercellular junction of the endothelium and then transmigrate to or even through the intercellular matrix. This is mediated by homophilic interactions of PECAM and CD31. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39097 NCIT_P366 "Granulocyte_Adhesion_Pathway" @default.
- NCIT_C39097 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39097 normalizedInformationContent "77.718057547374755" @default.
- NCIT_C39097 referenceCount "29" @default.
- NCIT_C39097 hasExactSynonym "Adhesion and Diapedesis of Granulocytes" @default.
- NCIT_C39097 hasExactSynonym "Granulocyte Adhesion Pathway" @default.
- NCIT_C39097 type Class @default.
- NCIT_C39097 isDefinedBy ncit.owl @default.
- NCIT_C39097 label "Granulocyte Adhesion Pathway" @default.
- NCIT_C39097 subClassOf NCIT_C20633 @default.
- NCIT_C39097 subClassOf NCIT_C39097 @default.
- NCIT_C39097 subClassOf NCIT_C39703 @default.