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- NCIT_C39104 NCIT_NHC0 "C39104" @default.
- NCIT_C39104 NCIT_P106 "Functional Concept" @default.
- NCIT_C39104 NCIT_P108 "Segmentation Clock Pathway" @default.
- NCIT_C39104 NCIT_P207 "C1519227" @default.
- NCIT_C39104 NCIT_P216 "h_hesPathway" @default.
- NCIT_C39104 NCIT_P325 "In most animal species, the anteroposterior body axis is generated by the formation of repeated structures called segments. In vertebrate segmentation, a specialized mesodermal structure called the somite gives rise to skeletal muscles, vertebrae, and some dermis. Formation of the somites is a rhythmic process that involves an oscillator, the segmentation clock, driven by Wnt and Notch signaling. The clock ticks in somite precursors and halts when they reach a specific maturation stage defined as the wavefront, established by FGF and Wnt signaling. Lunatic fringe was shown to act downstream of Notch and to bind and negatively regulate its own promoter. Another cyclic gene is hes1. It acts also downstream of Notch and codes for an unstable protein able to negatively regulate its own promoter too. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39104 NCIT_P366 "Segmentation_Clock_Pathway" @default.
- NCIT_C39104 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39104 normalizedInformationContent "76.863042570845906" @default.
- NCIT_C39104 referenceCount "33" @default.
- NCIT_C39104 hasExactSynonym "Segmentation Clock Pathway" @default.
- NCIT_C39104 hasExactSynonym "Segmentation Clock" @default.
- NCIT_C39104 type Class @default.
- NCIT_C39104 isDefinedBy ncit.owl @default.
- NCIT_C39104 label "Segmentation Clock Pathway" @default.
- NCIT_C39104 subClassOf NCIT_C20633 @default.
- NCIT_C39104 subClassOf NCIT_C39104 @default.
- NCIT_C39104 subClassOf NCIT_C39704 @default.