Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C39116> ?p ?o ?g. }
Showing items 1 to 20 of
20
with 100 items per page.
- NCIT_C39116 NCIT_NHC0 "C39116" @default.
- NCIT_C39116 NCIT_P106 "Functional Concept" @default.
- NCIT_C39116 NCIT_P108 "IL10 Anti-inflammatory Signaling Pathway" @default.
- NCIT_C39116 NCIT_P207 "C1512587" @default.
- NCIT_C39116 NCIT_P216 "h_il10Pathway" @default.
- NCIT_C39116 NCIT_P325 "IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by activated macrophages. The IL-10 receptor is in the JAK/STAT class of receptors but activation of the JAK/STAT pathways by IL-10 does not appear on its own to be responsible for the anti-inflammatory properties of this cytokine. The anti-inflammatory actions of IL-10 appear to require induction of the enzyme heme oxygenase-1 (HO-1) through a map kinase pathway involving the p38 kinases. HO-1 is involved in the biosynthesis of heme, and catalyzes a reaction producing carbon monoxide, free iron, and the heme precursor biliverdin. HO-1 is induced by IL-10 and is also induced by oxidative stress. Blocking HO-1 with inhibitors or antisense blocks the anti-inflammatory actions of IL-10. The anti-inflammatory actions of HO-1 appear to be the result of signaling by the carbon monoxide it produces since removal of CO blocks the anti-inflammatory action of IL-10 and HO-1. The anti-inflammatory actions of IL-10 may be therapeutically useful either directly or through modulation of HO-1 activity. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39116 NCIT_P366 "IL10_Anti-inflammatory_Signaling_Pathway" @default.
- NCIT_C39116 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39116 normalizedInformationContent "79.251926409996102" @default.
- NCIT_C39116 referenceCount "23" @default.
- NCIT_C39116 hasExactSynonym "IL-10 Anti-inflammatory Signaling Pathway" @default.
- NCIT_C39116 hasExactSynonym "IL10 Anti-inflammatory Signaling Pathway" @default.
- NCIT_C39116 type Class @default.
- NCIT_C39116 isDefinedBy ncit.owl @default.
- NCIT_C39116 label "IL10 Anti-inflammatory Signaling Pathway" @default.
- NCIT_C39116 subClassOf NCIT_C17132 @default.
- NCIT_C39116 subClassOf NCIT_C19779 @default.
- NCIT_C39116 subClassOf NCIT_C20633 @default.
- NCIT_C39116 subClassOf NCIT_C39116 @default.
- NCIT_C39116 subClassOf NCIT_C39698 @default.