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- NCIT_C39127 NCIT_NHC0 "C39127" @default.
- NCIT_C39127 NCIT_P106 "Functional Concept" @default.
- NCIT_C39127 NCIT_P108 "IL6 Signaling Pathway" @default.
- NCIT_C39127 NCIT_P207 "C1512598" @default.
- NCIT_C39127 NCIT_P216 "h_il6Pathway" @default.
- NCIT_C39127 NCIT_P325 "Interleukin-6 (IL-6) is a cytokine that provokes a broad range of cellular and physiological responses. In addition to playing a role in inflammation and hematopoiesis, IL-6 is involved in other processes such as neuronal differentiation and bone loss. To produce these effects IL-6 signals through a receptor composed of two different subunits, an alpha subunit that produces ligand specificity and gp130, a receptor subunit shared in common with other cytokines in the IL-6 family. Binding of IL-6 to its receptor initiates cellular events including activation of JAK kinases and activation of ras-mediated signaling. Activated JAK kinases phosphorylate and activate STAT transcription factors, particularly STAT3, that move into the nucleus to activate transcription of genes containing STAT3 response elements. The ras-mediated pathway, acting through Shc, Grb-2 and Sos-1 upstream and activating Map kinases downstream, activates transcription factors such as ELK-1 and NF-IL-6 (C/EBP-beta) that can act through their own cognate response elements in the genome. These factors and other transcription factors like AP-1 and SRF (serum response factor) that respond to many different signaling pathways come together to regulate a variety of complex promoters and enhancers that respond to IL-6 and other signaling factors. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39127 NCIT_P366 "IL6_Signaling_Pathway" @default.
- NCIT_C39127 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39127 normalizedInformationContent "76.287274181997702" @default.
- NCIT_C39127 referenceCount "36" @default.
- NCIT_C39127 hasExactSynonym "IL 6 signaling pathway" @default.
- NCIT_C39127 hasExactSynonym "IL6 Signaling Pathway" @default.
- NCIT_C39127 type Class @default.
- NCIT_C39127 isDefinedBy ncit.owl @default.
- NCIT_C39127 label "IL6 Signaling Pathway" @default.
- NCIT_C39127 subClassOf NCIT_C17132 @default.
- NCIT_C39127 subClassOf NCIT_C20633 @default.
- NCIT_C39127 subClassOf NCIT_C39127 @default.