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- NCIT_C39131 NCIT_NHC0 "C39131" @default.
- NCIT_C39131 NCIT_P106 "Functional Concept" @default.
- NCIT_C39131 NCIT_P108 "Integrin Signaling Pathway" @default.
- NCIT_C39131 NCIT_P207 "C1512812" @default.
- NCIT_C39131 NCIT_P216 "h_integrinPathway" @default.
- NCIT_C39131 NCIT_P325 "Integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals in response to the extracellular matrix including cellular shape, mobility, and progression through the cell cycle. Integrins do not themselves possess a kinase domain or enzymatic activity but rely on association with other signaling molecules to transmit signals. Interactions between the extracellular matrix and the actin cytoskeleton commonly take place at focal adhesions on the cell surface that contain localized concentrations of integrins, signaling molecules, and cytoskeletal elements. Talin forms a direct interaction with the integrin cytoplasmic domain, and interacts with cytoskeletal elements (actin) and signaling factors. Paxillin and CAS also localize in focal adhesions and may serve as a scaffold for other integrin signaling components like FAK and src. Interaction of FAK, CAS and src may be required for integrin regulation of cell cycle progression. The CrkL adaptor protein may regulate downstream integrin signaling. Growth factor signaling pathways and the caveolin receptor exhibit important cross talk with integrin receptors in cellular responses like activation of map kinase, proliferation and motility. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39131 NCIT_P366 "Integrin_Signaling_Pathway" @default.
- NCIT_C39131 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39131 normalizedInformationContent "73.018273635347086" @default.
- NCIT_C39131 referenceCount "59" @default.
- NCIT_C39131 hasExactSynonym "Integrin Signaling Pathway" @default.
- NCIT_C39131 type Class @default.
- NCIT_C39131 isDefinedBy ncit.owl @default.
- NCIT_C39131 label "Integrin Signaling Pathway" @default.
- NCIT_C39131 subClassOf NCIT_C17132 @default.
- NCIT_C39131 subClassOf NCIT_C20633 @default.
- NCIT_C39131 subClassOf NCIT_C39131 @default.