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- NCIT_C39135 NCIT_NHC0 "C39135" @default.
- NCIT_C39135 NCIT_P106 "Functional Concept" @default.
- NCIT_C39135 NCIT_P108 "Keratinocyte Differentiation Pathway" @default.
- NCIT_C39135 NCIT_P207 "C1521888" @default.
- NCIT_C39135 NCIT_P216 "h_keratinocytePathway" @default.
- NCIT_C39135 NCIT_P325 "The epidermis, which provides a protective barrier that undergoes a constant renewal, is a multi-layered tissue with the proliferating cells located in the basal layer. As cells leave the basal layer they undergo significant differentiation and biochemical and morphological remodeling. The final differentiation results in the formation of corneocytes. In vitro keratinocytes mimic this process. Several genes mark keratinocyte specific differentiation. Among the most frequently tracked markers are transglutaminase, cystatin and involucrin. Keratinocyte differentiation studies have identified and provided significant detail regarding the involvement of three of the 4 major MAP kinase pathways from several diverse stimuli such as EGF, FAS, TNF and calcium influx. The keratinocyte differentiation cascades also provide for detailed study of the functions of individual PKC isoforms and it is interesting to note the contrasting functions of the PKC isoforms in this process. In recent studies it has been determined that the cPKC (conventional/classical Protein Kinase C) isoforms, which are calcium-, phospholipid-, and diacylglycerol-dependent are inhibitory where as the nPKC (novel Protein Kinase C) isoforms which are calcium independent are stimulatory for keratinocyte differentiation markers. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39135 NCIT_P366 "Keratinocyte_Differentiation_Pathway" @default.
- NCIT_C39135 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39135 normalizedInformationContent "71.003419292665271" @default.
- NCIT_C39135 referenceCount "80" @default.
- NCIT_C39135 hasExactSynonym "Keratinocyte Differentiation Pathway" @default.
- NCIT_C39135 hasExactSynonym "Keratinocyte Differentiation" @default.
- NCIT_C39135 type Class @default.
- NCIT_C39135 isDefinedBy ncit.owl @default.
- NCIT_C39135 label "Keratinocyte Differentiation Pathway" @default.
- NCIT_C39135 subClassOf NCIT_C20633 @default.
- NCIT_C39135 subClassOf NCIT_C39135 @default.
- NCIT_C39135 subClassOf NCIT_C39704 @default.