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- NCIT_C39145 NCIT_NHC0 "C39145" @default.
- NCIT_C39145 NCIT_P106 "Functional Concept" @default.
- NCIT_C39145 NCIT_P108 "SRF Activation Pathway" @default.
- NCIT_C39145 NCIT_P207 "C1519155" @default.
- NCIT_C39145 NCIT_P216 "h_malPathway" @default.
- NCIT_C39145 NCIT_P325 "Serum response factor (SRF) is a transcription factor, which binds to a serum response element (SRE) associated with a variety of genes including immediate early genes such as c-fos, fosB, junB, egr-1 and -2, neuronal genes such as nurr1 and nur77, and muscle genes such as actins and myosins. By regulating expression of these genes, SRF controls cell growth and differentiation, neuronal transmission, as well as muscle development and function. SRF can be activated by serum, lysophosphatidic acid (LPA), lipopolysaccharide (LPS), 12-O-tetradecanoylphorbol-13-acetate (TPA), cytokines, tumor necrosis factor-alpha (TNFalpha), agents that increase intracellular Ca2+, T-cell virus1 activator protein, hepatitis B virus activator proteins pX, activated oncogenes and protooncogenes, and extracellular stimuli such as antioxidant and UV light. In serum-starved cells, MAL is predominantly cytoplasmic where it is sequestered by actin monomers. Upon serum stimulation, Rho becomes active and, through its interaction with ROCK and mDia1, causes an accumulation of F-actin and a commensurate decrease in the level of G-actin. As a consequence, MAL is no longer sequestered and is free to translocate to the nucleus where it associates with SRF and activates SRE-mediated gene expression. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39145 NCIT_P366 "SRF_Activation_Pathway" @default.
- NCIT_C39145 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39145 normalizedInformationContent "76.863042570845906" @default.
- NCIT_C39145 referenceCount "33" @default.
- NCIT_C39145 hasExactSynonym "Role of MAL in Rho-Mediated Activation of SRF" @default.
- NCIT_C39145 hasExactSynonym "SRF Activation Pathway" @default.
- NCIT_C39145 type Class @default.
- NCIT_C39145 isDefinedBy ncit.owl @default.
- NCIT_C39145 label "SRF Activation Pathway" @default.
- NCIT_C39145 subClassOf NCIT_C19779 @default.
- NCIT_C39145 subClassOf NCIT_C20633 @default.
- NCIT_C39145 subClassOf NCIT_C39145 @default.
- NCIT_C39145 subClassOf NCIT_C40420 @default.