Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C39146> ?p ?o ?g. }
Showing items 1 to 17 of
17
with 100 items per page.
- NCIT_C39146 NCIT_NHC0 "C39146" @default.
- NCIT_C39146 NCIT_P106 "Functional Concept" @default.
- NCIT_C39146 NCIT_P108 "MAPKinase Signaling Pathway" @default.
- NCIT_C39146 NCIT_P207 "C1518103" @default.
- NCIT_C39146 NCIT_P216 "h_mapkPathway" @default.
- NCIT_C39146 NCIT_P325 "The ever evolving mitogen-activated protein kinase (MAP kinase) pathways consist of four major groupings and numerous related proteins which constitute interrelated signal transduction cascades activated by stimuli such as growth factors, stress, cytokines and inflammation. The four major groupings are the Erk, JNK or SAPK, p38, and the Big MAPK or ERK5 cascades. Signals from cell surface receptors such as GPCRs and growth factor receptors are transduced, directly or via small G proteins such as ras and rac, to multiple tiers of protein kinases that amplify these signals and/or regulate each other. In some cascades the first activation tier involves the MAPKKKKs, MAP kinase kinase kinase kinases or MAP4K proteins. The next tier are the serine/threonine MAPKKKs, MAP kinase kinase kinase or MAP3Ks such as RAF, TAK, ASK, and MEKK1. This level has the greatest amount of cross-communication currently known. The serine/threonine/tyrosine MAPKKs, MAP Kinase kinases or MAP2Ks, such as the MKK and MEK kinases, are one step up from the MAP kinase cascade, phosphorylating and activating these kinases. The focal tier, the MAPKs or MAP kinases includes JNK1, p38, and ERKs, and are the kinases that give each cascade its name. The endpoints of these cascades include the MAPK activated protein kinases (MAPKAPK) and some of the numerous transcription factors that regulate genes involved in apoptosis, inflammation, cell growth and differentiation. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39146 NCIT_P366 "MAPKinase_Signaling_Pathway" @default.
- NCIT_C39146 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39146 normalizedInformationContent "68.65980697877589" @default.
- NCIT_C39146 referenceCount "114" @default.
- NCIT_C39146 hasExactSynonym "MAPKinase Signaling Pathway" @default.
- NCIT_C39146 type Class @default.
- NCIT_C39146 isDefinedBy ncit.owl @default.
- NCIT_C39146 label "MAPKinase Signaling Pathway" @default.
- NCIT_C39146 subClassOf NCIT_C17132 @default.
- NCIT_C39146 subClassOf NCIT_C20633 @default.
- NCIT_C39146 subClassOf NCIT_C39146 @default.